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Impact of Specific Bowel Symptoms on Quality of Life in Patients with Midgut Neuroendocrine Tumours

INTRODUCTION: Patients with midgut neuroendocrine tumours (NETs) suffer from decreased health-related quality of life (HRQoL), in large part due to bowel symptoms. However, it is unknown which bowel symptoms affect HRQoL the most. An enhanced understanding of this is essential to better focus treatm...

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Autores principales: Ohlsson, Håkan, Wahlberg, Gideon, Malmström, Marlene, Gustafsson, Rita, Sundlöv, Anna, Nordenström, Erik, Almquist, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321966/
https://www.ncbi.nlm.nih.gov/pubmed/33969447
http://dx.doi.org/10.1007/s00268-021-06146-9
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author Ohlsson, Håkan
Wahlberg, Gideon
Malmström, Marlene
Gustafsson, Rita
Sundlöv, Anna
Nordenström, Erik
Almquist, Martin
author_facet Ohlsson, Håkan
Wahlberg, Gideon
Malmström, Marlene
Gustafsson, Rita
Sundlöv, Anna
Nordenström, Erik
Almquist, Martin
author_sort Ohlsson, Håkan
collection PubMed
description INTRODUCTION: Patients with midgut neuroendocrine tumours (NETs) suffer from decreased health-related quality of life (HRQoL), in large part due to bowel symptoms. However, it is unknown which bowel symptoms affect HRQoL the most. An enhanced understanding of this is essential to better focus treatment on this aspect of the disease. This study aimed to determine which bowel symptoms affect HRQoL the most in patients with midgut NETs. METHODS: Consenting patients with midgut NET completed the Memorial Sloan Kettering Bowel Function Instrument and the HRQoL questionnaire (EORTC QLQ-C30). The correlation between bowel symptoms and HRQoL was analysed using multiple linear regression, adjusting for age, Charlson Comorbidity Index score, presence of metastatic disease, chromogranin A, and BMI yielding ß-coefficients with 95% confidence intervals. RESULTS: Totally, 119 patients with midgut NET completed the questionnaires and were included in the study. Loose stool and bowel frequency ≥ 3/day were the most common bowel symptoms, reported by 47% and 56% of patients, respectively. However, sensitivity to certain types of food and beverages, a feeling of incomplete emptying of the bowel, and soiling were the symptoms most strongly correlated with decreased HRQoL, especially within domains concerning role and social function, with ß-coefficients for the strongest correlated symptoms of 15.0 and 14.6, respectively. DISCUSSION: While symptoms concerning stool consistency and frequency are common in patients with midgut NET, our study suggests that other, more socially stigmatising symptoms affect patients’ HRQoL more. Our findings could help caregivers understand patients’ perceptions of the disease and provide avenues for more directed therapies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00268-021-06146-9.
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spelling pubmed-83219662021-08-19 Impact of Specific Bowel Symptoms on Quality of Life in Patients with Midgut Neuroendocrine Tumours Ohlsson, Håkan Wahlberg, Gideon Malmström, Marlene Gustafsson, Rita Sundlöv, Anna Nordenström, Erik Almquist, Martin World J Surg Original Scientific Report INTRODUCTION: Patients with midgut neuroendocrine tumours (NETs) suffer from decreased health-related quality of life (HRQoL), in large part due to bowel symptoms. However, it is unknown which bowel symptoms affect HRQoL the most. An enhanced understanding of this is essential to better focus treatment on this aspect of the disease. This study aimed to determine which bowel symptoms affect HRQoL the most in patients with midgut NETs. METHODS: Consenting patients with midgut NET completed the Memorial Sloan Kettering Bowel Function Instrument and the HRQoL questionnaire (EORTC QLQ-C30). The correlation between bowel symptoms and HRQoL was analysed using multiple linear regression, adjusting for age, Charlson Comorbidity Index score, presence of metastatic disease, chromogranin A, and BMI yielding ß-coefficients with 95% confidence intervals. RESULTS: Totally, 119 patients with midgut NET completed the questionnaires and were included in the study. Loose stool and bowel frequency ≥ 3/day were the most common bowel symptoms, reported by 47% and 56% of patients, respectively. However, sensitivity to certain types of food and beverages, a feeling of incomplete emptying of the bowel, and soiling were the symptoms most strongly correlated with decreased HRQoL, especially within domains concerning role and social function, with ß-coefficients for the strongest correlated symptoms of 15.0 and 14.6, respectively. DISCUSSION: While symptoms concerning stool consistency and frequency are common in patients with midgut NET, our study suggests that other, more socially stigmatising symptoms affect patients’ HRQoL more. Our findings could help caregivers understand patients’ perceptions of the disease and provide avenues for more directed therapies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00268-021-06146-9. Springer International Publishing 2021-05-09 2021 /pmc/articles/PMC8321966/ /pubmed/33969447 http://dx.doi.org/10.1007/s00268-021-06146-9 Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Scientific Report
Ohlsson, Håkan
Wahlberg, Gideon
Malmström, Marlene
Gustafsson, Rita
Sundlöv, Anna
Nordenström, Erik
Almquist, Martin
Impact of Specific Bowel Symptoms on Quality of Life in Patients with Midgut Neuroendocrine Tumours
title Impact of Specific Bowel Symptoms on Quality of Life in Patients with Midgut Neuroendocrine Tumours
title_full Impact of Specific Bowel Symptoms on Quality of Life in Patients with Midgut Neuroendocrine Tumours
title_fullStr Impact of Specific Bowel Symptoms on Quality of Life in Patients with Midgut Neuroendocrine Tumours
title_full_unstemmed Impact of Specific Bowel Symptoms on Quality of Life in Patients with Midgut Neuroendocrine Tumours
title_short Impact of Specific Bowel Symptoms on Quality of Life in Patients with Midgut Neuroendocrine Tumours
title_sort impact of specific bowel symptoms on quality of life in patients with midgut neuroendocrine tumours
topic Original Scientific Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321966/
https://www.ncbi.nlm.nih.gov/pubmed/33969447
http://dx.doi.org/10.1007/s00268-021-06146-9
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