Genetic analysis of human parainfluenza virus type 4 associated with severe acute respiratory infection in children in Luohe City, Henan Province, China, during 2017–2018

During 2017–2018, nasopharyngeal aspirates (NPAs) from 627 hospitalized patients with severe acute respiratory infection at Luohe Center Hospital were tested by RT-PCR for human parainfluenza virus 4 (HPIV-4). Fourteen (2.2%) of the 627 samples were positive for HPIV-4. The complete HN gene was ampl...

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Autores principales: Zhou, Shanshan, Mao, Naiying, Zhang, Yan, Cui, Aili, Zhu, Zhen, Hu, Ruiping, Xu, Jin, Xu, Wenbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321989/
https://www.ncbi.nlm.nih.gov/pubmed/34231027
http://dx.doi.org/10.1007/s00705-021-05154-3
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author Zhou, Shanshan
Mao, Naiying
Zhang, Yan
Cui, Aili
Zhu, Zhen
Hu, Ruiping
Xu, Jin
Xu, Wenbo
author_facet Zhou, Shanshan
Mao, Naiying
Zhang, Yan
Cui, Aili
Zhu, Zhen
Hu, Ruiping
Xu, Jin
Xu, Wenbo
author_sort Zhou, Shanshan
collection PubMed
description During 2017–2018, nasopharyngeal aspirates (NPAs) from 627 hospitalized patients with severe acute respiratory infection at Luohe Center Hospital were tested by RT-PCR for human parainfluenza virus 4 (HPIV-4). Fourteen (2.2%) of the 627 samples were positive for HPIV-4. The complete HN gene was amplified from nine positive samples and sequenced. Sequence comparisons showed that the HPIV-4 strains circulating in the city of Luohe are closely related to HPIV-4A strains. Our study indicated that there were multiple lineages of HPIV-4 circulating in Henan Province in China during the study period. This will improve our understanding of the epidemiological and clinical characteristics of HPIV-4. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00705-021-05154-3.
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spelling pubmed-83219892021-08-19 Genetic analysis of human parainfluenza virus type 4 associated with severe acute respiratory infection in children in Luohe City, Henan Province, China, during 2017–2018 Zhou, Shanshan Mao, Naiying Zhang, Yan Cui, Aili Zhu, Zhen Hu, Ruiping Xu, Jin Xu, Wenbo Arch Virol Brief Report During 2017–2018, nasopharyngeal aspirates (NPAs) from 627 hospitalized patients with severe acute respiratory infection at Luohe Center Hospital were tested by RT-PCR for human parainfluenza virus 4 (HPIV-4). Fourteen (2.2%) of the 627 samples were positive for HPIV-4. The complete HN gene was amplified from nine positive samples and sequenced. Sequence comparisons showed that the HPIV-4 strains circulating in the city of Luohe are closely related to HPIV-4A strains. Our study indicated that there were multiple lineages of HPIV-4 circulating in Henan Province in China during the study period. This will improve our understanding of the epidemiological and clinical characteristics of HPIV-4. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00705-021-05154-3. Springer Vienna 2021-07-06 2021 /pmc/articles/PMC8321989/ /pubmed/34231027 http://dx.doi.org/10.1007/s00705-021-05154-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Report
Zhou, Shanshan
Mao, Naiying
Zhang, Yan
Cui, Aili
Zhu, Zhen
Hu, Ruiping
Xu, Jin
Xu, Wenbo
Genetic analysis of human parainfluenza virus type 4 associated with severe acute respiratory infection in children in Luohe City, Henan Province, China, during 2017–2018
title Genetic analysis of human parainfluenza virus type 4 associated with severe acute respiratory infection in children in Luohe City, Henan Province, China, during 2017–2018
title_full Genetic analysis of human parainfluenza virus type 4 associated with severe acute respiratory infection in children in Luohe City, Henan Province, China, during 2017–2018
title_fullStr Genetic analysis of human parainfluenza virus type 4 associated with severe acute respiratory infection in children in Luohe City, Henan Province, China, during 2017–2018
title_full_unstemmed Genetic analysis of human parainfluenza virus type 4 associated with severe acute respiratory infection in children in Luohe City, Henan Province, China, during 2017–2018
title_short Genetic analysis of human parainfluenza virus type 4 associated with severe acute respiratory infection in children in Luohe City, Henan Province, China, during 2017–2018
title_sort genetic analysis of human parainfluenza virus type 4 associated with severe acute respiratory infection in children in luohe city, henan province, china, during 2017–2018
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321989/
https://www.ncbi.nlm.nih.gov/pubmed/34231027
http://dx.doi.org/10.1007/s00705-021-05154-3
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