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Effects of head trauma and sport participation in young-onset Parkinson’s disease

Head trauma (HT) is emerging as an event anticipating onset of neurodegenerative disorders. However, the potential contribution of HT in young-onset cases (YOPD, age at onset < 50) of Parkinson’s disease (PD) has not been examined yet. Here, we systematically assessed HT history in PD patients to...

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Autores principales: Schirinzi, Tommaso, Grillo, Piergiorgio, Di Lazzaro, Giulia, Zenuni, Henri, Salimei, Chiara, Dams-O’Connor, Kristen, Sancesario, Giulia Maria, Mercuri, Nicola Biagio, Pisani, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322011/
https://www.ncbi.nlm.nih.gov/pubmed/34263354
http://dx.doi.org/10.1007/s00702-021-02370-8
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author Schirinzi, Tommaso
Grillo, Piergiorgio
Di Lazzaro, Giulia
Zenuni, Henri
Salimei, Chiara
Dams-O’Connor, Kristen
Sancesario, Giulia Maria
Mercuri, Nicola Biagio
Pisani, Antonio
author_facet Schirinzi, Tommaso
Grillo, Piergiorgio
Di Lazzaro, Giulia
Zenuni, Henri
Salimei, Chiara
Dams-O’Connor, Kristen
Sancesario, Giulia Maria
Mercuri, Nicola Biagio
Pisani, Antonio
author_sort Schirinzi, Tommaso
collection PubMed
description Head trauma (HT) is emerging as an event anticipating onset of neurodegenerative disorders. However, the potential contribution of HT in young-onset cases (YOPD, age at onset < 50) of Parkinson’s disease (PD) has not been examined yet. Here, we systematically assessed HT history in PD patients to estimate the risk associated, especially in terms of age of onset, and define the correlations with the clinical-biochemical profile. The Brain Injury Screening Questionnaire (BISQ) was administered to 94 PD patients (31 with YOPD, known monogenic forms excluded) and 70 controls. HT history was correlated with motor and non-motor scores in all patients, and to CSF biomarkers of neurodegeneration (α-synuclein, amyloid-β42, total and phosporiled-181 tau, lactate, CSF/serum albumin) into a subgroup. HT increased the risk for both PD and YOPD. In PD patients, but not in those with YOPD, the number of HTs directly correlated with CSF total-tau levels. No other correlations resulted between HT and clinical parameters. Sport-related HT was a specific risk factor for YOPD; conversely, the prolonged sporting life represented a protective factor. HTs can favor PD onset, even as YOPD. Sport-related HT resulted a risk factor for YOPD, although the longer sporting practice delayed PD onset, protecting from YOPD. Tauopathy may underlie the overall association between HT and PD. Additional mechanisms could be instead implicated in HT contribution to YOPD onset.
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spelling pubmed-83220112021-08-19 Effects of head trauma and sport participation in young-onset Parkinson’s disease Schirinzi, Tommaso Grillo, Piergiorgio Di Lazzaro, Giulia Zenuni, Henri Salimei, Chiara Dams-O’Connor, Kristen Sancesario, Giulia Maria Mercuri, Nicola Biagio Pisani, Antonio J Neural Transm (Vienna) Neurology and Preclinical Neurological Studies - Original Article Head trauma (HT) is emerging as an event anticipating onset of neurodegenerative disorders. However, the potential contribution of HT in young-onset cases (YOPD, age at onset < 50) of Parkinson’s disease (PD) has not been examined yet. Here, we systematically assessed HT history in PD patients to estimate the risk associated, especially in terms of age of onset, and define the correlations with the clinical-biochemical profile. The Brain Injury Screening Questionnaire (BISQ) was administered to 94 PD patients (31 with YOPD, known monogenic forms excluded) and 70 controls. HT history was correlated with motor and non-motor scores in all patients, and to CSF biomarkers of neurodegeneration (α-synuclein, amyloid-β42, total and phosporiled-181 tau, lactate, CSF/serum albumin) into a subgroup. HT increased the risk for both PD and YOPD. In PD patients, but not in those with YOPD, the number of HTs directly correlated with CSF total-tau levels. No other correlations resulted between HT and clinical parameters. Sport-related HT was a specific risk factor for YOPD; conversely, the prolonged sporting life represented a protective factor. HTs can favor PD onset, even as YOPD. Sport-related HT resulted a risk factor for YOPD, although the longer sporting practice delayed PD onset, protecting from YOPD. Tauopathy may underlie the overall association between HT and PD. Additional mechanisms could be instead implicated in HT contribution to YOPD onset. Springer Vienna 2021-07-14 2021 /pmc/articles/PMC8322011/ /pubmed/34263354 http://dx.doi.org/10.1007/s00702-021-02370-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Neurology and Preclinical Neurological Studies - Original Article
Schirinzi, Tommaso
Grillo, Piergiorgio
Di Lazzaro, Giulia
Zenuni, Henri
Salimei, Chiara
Dams-O’Connor, Kristen
Sancesario, Giulia Maria
Mercuri, Nicola Biagio
Pisani, Antonio
Effects of head trauma and sport participation in young-onset Parkinson’s disease
title Effects of head trauma and sport participation in young-onset Parkinson’s disease
title_full Effects of head trauma and sport participation in young-onset Parkinson’s disease
title_fullStr Effects of head trauma and sport participation in young-onset Parkinson’s disease
title_full_unstemmed Effects of head trauma and sport participation in young-onset Parkinson’s disease
title_short Effects of head trauma and sport participation in young-onset Parkinson’s disease
title_sort effects of head trauma and sport participation in young-onset parkinson’s disease
topic Neurology and Preclinical Neurological Studies - Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322011/
https://www.ncbi.nlm.nih.gov/pubmed/34263354
http://dx.doi.org/10.1007/s00702-021-02370-8
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