Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1

Long-lasting cognitive impairment in juveniles undergoing repeated general anesthesia has been observed in numerous preclinical and clinical studies, yet, the underlying mechanisms remain unknown and no preventive treatment is available. We found that daily intranasal insulin administration to juven...

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Detalles Bibliográficos
Autores principales: Roque, Patricia Soriano, Hooshmandi, Mehdi, Neagu-Lund, Laura, Yin, Shelly, Yousefpour, Noosha, Sato, Hiroaki, Sato, Tamaki, Nakadate, Yosuke, Kawakami, Akiko, Tahmasebi, Soroush, Ribeiro-da-Silva, Alfredo, Gkogkas, Christos G., Prager-Khoutorsky, Masha, Schricker, Thomas, Wykes, Linda, Khoutorsky, Arkady
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322102/
https://www.ncbi.nlm.nih.gov/pubmed/34326413
http://dx.doi.org/10.1038/s41598-021-94849-3

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