Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model

Hearing impairment is one of the complications in diabetes mellitus; however, there are very few therapeutic studies on it. In this study, we investigated the protective effect of alpha-lipoic acid (ALA) on hearing loss in diabetic transgenic zebrafish and confirmed that ALA protects the loss of hai...

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Detalles Bibliográficos
Autores principales: Kim, Eunmi, Lee, Dong-Won, Park, Hae-Chul, Kim, Dong Hwee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322127/
https://www.ncbi.nlm.nih.gov/pubmed/34354927
http://dx.doi.org/10.1016/j.ymgmr.2021.100783
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author Kim, Eunmi
Lee, Dong-Won
Park, Hae-Chul
Kim, Dong Hwee
author_facet Kim, Eunmi
Lee, Dong-Won
Park, Hae-Chul
Kim, Dong Hwee
author_sort Kim, Eunmi
collection PubMed
description Hearing impairment is one of the complications in diabetes mellitus; however, there are very few therapeutic studies on it. In this study, we investigated the protective effect of alpha-lipoic acid (ALA) on hearing loss in diabetic transgenic zebrafish and confirmed that ALA protects the loss of hair cells (HCs) caused by hyperglycemia. The data indicated that ALA has a protective effect on the damage to HCs in diabetic zebrafish.
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spelling pubmed-83221272021-08-04 Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model Kim, Eunmi Lee, Dong-Won Park, Hae-Chul Kim, Dong Hwee Mol Genet Metab Rep Short Communication Hearing impairment is one of the complications in diabetes mellitus; however, there are very few therapeutic studies on it. In this study, we investigated the protective effect of alpha-lipoic acid (ALA) on hearing loss in diabetic transgenic zebrafish and confirmed that ALA protects the loss of hair cells (HCs) caused by hyperglycemia. The data indicated that ALA has a protective effect on the damage to HCs in diabetic zebrafish. Elsevier 2021-07-21 /pmc/articles/PMC8322127/ /pubmed/34354927 http://dx.doi.org/10.1016/j.ymgmr.2021.100783 Text en © 2021 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Kim, Eunmi
Lee, Dong-Won
Park, Hae-Chul
Kim, Dong Hwee
Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model
title Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model
title_full Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model
title_fullStr Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model
title_full_unstemmed Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model
title_short Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model
title_sort protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322127/
https://www.ncbi.nlm.nih.gov/pubmed/34354927
http://dx.doi.org/10.1016/j.ymgmr.2021.100783
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AT parkhaechul protectiveeffectsofalphalipoicacidonhaircelldamageindiabeticzebrafishmodel
AT kimdonghwee protectiveeffectsofalphalipoicacidonhaircelldamageindiabeticzebrafishmodel

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