BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination

BRCA2 and its interactors are required for meiotic homologous recombination (HR) and fertility. Loss of HSF2BP, a BRCA2 interactor, disrupts HR during spermatogenesis. We test the model postulating that HSF2BP localizes BRCA2 to meiotic HR sites, by solving the crystal structure of the BRCA2 fragmen...

Descripción completa

Detalles Bibliográficos
Autores principales: Ghouil, Rania, Miron, Simona, Koornneef, Lieke, Veerman, Jasper, Paul, Maarten W., Le Du, Marie-Hélène, Sleddens-Linkels, Esther, van Rossum-Fikkert, Sari E., van Loon, Yvette, Felipe-Medina, Natalia, Pendas, Alberto M., Maas, Alex, Essers, Jeroen, Legrand, Pierre, Baarends, Willy M., Kanaar, Roland, Zinn-Justin, Sophie, Zelensky, Alex N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322138/
https://www.ncbi.nlm.nih.gov/pubmed/34326328
http://dx.doi.org/10.1038/s41467-021-24871-6

Ejemplares similares

Ejemplares similares