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Structural studies of elastic fibre and microfibrillar proteins

Elastic tissues owe their functional properties to the composition of their extracellular matrices, particularly the range of extracellular, multidomain extensible elastic fibre and microfibrillar proteins. These proteins include elastin, fibrillin, latent TGFβ binding proteins (LTBPs) and collagens...

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Detalles Bibliográficos
Autores principales: Singh, Mukti, Becker, Mark, Godwin, Alan R.F., Baldock, Clair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322146/
https://www.ncbi.nlm.nih.gov/pubmed/34355160
http://dx.doi.org/10.1016/j.mbplus.2021.100078
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author Singh, Mukti
Becker, Mark
Godwin, Alan R.F.
Baldock, Clair
author_facet Singh, Mukti
Becker, Mark
Godwin, Alan R.F.
Baldock, Clair
author_sort Singh, Mukti
collection PubMed
description Elastic tissues owe their functional properties to the composition of their extracellular matrices, particularly the range of extracellular, multidomain extensible elastic fibre and microfibrillar proteins. These proteins include elastin, fibrillin, latent TGFβ binding proteins (LTBPs) and collagens, where their biophysical and biochemical properties not only give the matrix structural integrity, but also play a vital role in the mechanisms that underlie tissue homeostasis. Thus far structural information regarding the structure and hierarchical assembly of these molecules has been challenging and the resolution has been limited due to post-translational modification and their multidomain nature leading to flexibility, which together result in conformational and structural heterogeneity. In this review, we describe some of the matrix proteins found in elastic fibres and the new emerging techniques that can shed light on their structure and dynamic properties.
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spelling pubmed-83221462021-08-04 Structural studies of elastic fibre and microfibrillar proteins Singh, Mukti Becker, Mark Godwin, Alan R.F. Baldock, Clair Matrix Biol Plus Special Section on Molecular and Supramolecular structure of the extracellular matrix; Edited by Sylvie Ricard-Blum. Elastic tissues owe their functional properties to the composition of their extracellular matrices, particularly the range of extracellular, multidomain extensible elastic fibre and microfibrillar proteins. These proteins include elastin, fibrillin, latent TGFβ binding proteins (LTBPs) and collagens, where their biophysical and biochemical properties not only give the matrix structural integrity, but also play a vital role in the mechanisms that underlie tissue homeostasis. Thus far structural information regarding the structure and hierarchical assembly of these molecules has been challenging and the resolution has been limited due to post-translational modification and their multidomain nature leading to flexibility, which together result in conformational and structural heterogeneity. In this review, we describe some of the matrix proteins found in elastic fibres and the new emerging techniques that can shed light on their structure and dynamic properties. Elsevier 2021-07-07 /pmc/articles/PMC8322146/ /pubmed/34355160 http://dx.doi.org/10.1016/j.mbplus.2021.100078 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Special Section on Molecular and Supramolecular structure of the extracellular matrix; Edited by Sylvie Ricard-Blum.
Singh, Mukti
Becker, Mark
Godwin, Alan R.F.
Baldock, Clair
Structural studies of elastic fibre and microfibrillar proteins
title Structural studies of elastic fibre and microfibrillar proteins
title_full Structural studies of elastic fibre and microfibrillar proteins
title_fullStr Structural studies of elastic fibre and microfibrillar proteins
title_full_unstemmed Structural studies of elastic fibre and microfibrillar proteins
title_short Structural studies of elastic fibre and microfibrillar proteins
title_sort structural studies of elastic fibre and microfibrillar proteins
topic Special Section on Molecular and Supramolecular structure of the extracellular matrix; Edited by Sylvie Ricard-Blum.
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322146/
https://www.ncbi.nlm.nih.gov/pubmed/34355160
http://dx.doi.org/10.1016/j.mbplus.2021.100078
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