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Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection

SARS-CoV-2 infection can affect all human beings, including pregnant women. Thus, understanding the immunological changes induced by the virus during pregnancy is nowadays of pivotal importance. Here, using peripheral blood from 14 pregnant women with asymptomatic or mild SARS-CoV-2 infection, we in...

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Autores principales: De Biasi, Sara, Tartaro, Domenico Lo, Gibellini, Lara, Paolini, Annamaria, Quong, Andrew, Petes, Carlene, Awong, Geneve, Douglas, Samuel, Lin, Dongxia, Nieto, Jordan, Galassi, Francesco Maria, Borella, Rebecca, Fidanza, Lucia, Mattioli, Marco, Leone, Chiara, Neri, Isabella, Meschiari, Marianna, Cicchetti, Luca, Iannone, Anna, Trenti, Tommaso, Sarti, Mario, Girardis, Massimo, Guaraldi, Giovanni, Mussini, Cristina, Facchinetti, Fabio, Cossarizza, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322155/
https://www.ncbi.nlm.nih.gov/pubmed/34326336
http://dx.doi.org/10.1038/s41467-021-24940-w
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author De Biasi, Sara
Tartaro, Domenico Lo
Gibellini, Lara
Paolini, Annamaria
Quong, Andrew
Petes, Carlene
Awong, Geneve
Douglas, Samuel
Lin, Dongxia
Nieto, Jordan
Galassi, Francesco Maria
Borella, Rebecca
Fidanza, Lucia
Mattioli, Marco
Leone, Chiara
Neri, Isabella
Meschiari, Marianna
Cicchetti, Luca
Iannone, Anna
Trenti, Tommaso
Sarti, Mario
Girardis, Massimo
Guaraldi, Giovanni
Mussini, Cristina
Facchinetti, Fabio
Cossarizza, Andrea
author_facet De Biasi, Sara
Tartaro, Domenico Lo
Gibellini, Lara
Paolini, Annamaria
Quong, Andrew
Petes, Carlene
Awong, Geneve
Douglas, Samuel
Lin, Dongxia
Nieto, Jordan
Galassi, Francesco Maria
Borella, Rebecca
Fidanza, Lucia
Mattioli, Marco
Leone, Chiara
Neri, Isabella
Meschiari, Marianna
Cicchetti, Luca
Iannone, Anna
Trenti, Tommaso
Sarti, Mario
Girardis, Massimo
Guaraldi, Giovanni
Mussini, Cristina
Facchinetti, Fabio
Cossarizza, Andrea
author_sort De Biasi, Sara
collection PubMed
description SARS-CoV-2 infection can affect all human beings, including pregnant women. Thus, understanding the immunological changes induced by the virus during pregnancy is nowadays of pivotal importance. Here, using peripheral blood from 14 pregnant women with asymptomatic or mild SARS-CoV-2 infection, we investigate cell proliferation and cytokine production, measure plasma levels of 62 cytokines, and perform a 38-parameter mass cytometry analysis. Our results show an increase in low density neutrophils but no lymphopenia or gross alterations of white blood cells, which display normal levels of differentiation, activation or exhaustion markers and show well preserved functionality. Meanwhile, the plasma levels of anti-inflammatory cytokines such as interleukin (IL)-1RA, IL-10 and IL-19 are increased, those of IL-17, PD-L1 and D-dimer are decreased, but IL-6 and other inflammatory molecules remain unchanged. Our profiling of antiviral immune responses may thus help develop therapeutic strategies to avoid virus-induced damages during pregnancy.
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spelling pubmed-83221552021-08-03 Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection De Biasi, Sara Tartaro, Domenico Lo Gibellini, Lara Paolini, Annamaria Quong, Andrew Petes, Carlene Awong, Geneve Douglas, Samuel Lin, Dongxia Nieto, Jordan Galassi, Francesco Maria Borella, Rebecca Fidanza, Lucia Mattioli, Marco Leone, Chiara Neri, Isabella Meschiari, Marianna Cicchetti, Luca Iannone, Anna Trenti, Tommaso Sarti, Mario Girardis, Massimo Guaraldi, Giovanni Mussini, Cristina Facchinetti, Fabio Cossarizza, Andrea Nat Commun Article SARS-CoV-2 infection can affect all human beings, including pregnant women. Thus, understanding the immunological changes induced by the virus during pregnancy is nowadays of pivotal importance. Here, using peripheral blood from 14 pregnant women with asymptomatic or mild SARS-CoV-2 infection, we investigate cell proliferation and cytokine production, measure plasma levels of 62 cytokines, and perform a 38-parameter mass cytometry analysis. Our results show an increase in low density neutrophils but no lymphopenia or gross alterations of white blood cells, which display normal levels of differentiation, activation or exhaustion markers and show well preserved functionality. Meanwhile, the plasma levels of anti-inflammatory cytokines such as interleukin (IL)-1RA, IL-10 and IL-19 are increased, those of IL-17, PD-L1 and D-dimer are decreased, but IL-6 and other inflammatory molecules remain unchanged. Our profiling of antiviral immune responses may thus help develop therapeutic strategies to avoid virus-induced damages during pregnancy. Nature Publishing Group UK 2021-07-29 /pmc/articles/PMC8322155/ /pubmed/34326336 http://dx.doi.org/10.1038/s41467-021-24940-w Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
De Biasi, Sara
Tartaro, Domenico Lo
Gibellini, Lara
Paolini, Annamaria
Quong, Andrew
Petes, Carlene
Awong, Geneve
Douglas, Samuel
Lin, Dongxia
Nieto, Jordan
Galassi, Francesco Maria
Borella, Rebecca
Fidanza, Lucia
Mattioli, Marco
Leone, Chiara
Neri, Isabella
Meschiari, Marianna
Cicchetti, Luca
Iannone, Anna
Trenti, Tommaso
Sarti, Mario
Girardis, Massimo
Guaraldi, Giovanni
Mussini, Cristina
Facchinetti, Fabio
Cossarizza, Andrea
Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection
title Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection
title_full Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection
title_fullStr Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection
title_full_unstemmed Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection
title_short Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection
title_sort endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic sars-cov-2 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322155/
https://www.ncbi.nlm.nih.gov/pubmed/34326336
http://dx.doi.org/10.1038/s41467-021-24940-w
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