Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity

The transcriptional co-activator and acetyltransferase p300 is required for fundamental cellular processes, including differentiation and growth. Here, we report that p300 forms phase separated condensates in the cell nucleus. The phase separation ability of p300 is regulated by autoacetylation and...

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Detalles Bibliográficos
Autores principales: Zhang, Yi, Brown, Kyle, Yu, Yucong, Ibrahim, Ziad, Zandian, Mohamad, Xuan, Hongwen, Ingersoll, Steven, Lee, Thomas, Ebmeier, Christopher C., Liu, Jiuyang, Panne, Daniel, Shi, Xiaobing, Ren, Xiaojun, Kutateladze, Tatiana G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322156/
https://www.ncbi.nlm.nih.gov/pubmed/34326347
http://dx.doi.org/10.1038/s41467-021-24950-8

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