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Chronic activation of 4-1BB signaling induces granuloma development in tumor-draining lymph nodes that is detrimental to subsequent CD8(+) T cell responses

The antitumor capabilities of agonistic anti-4-1BB mAbs have made them an attractive target for tumor immunotherapy. However, the adverse side effects associated with agonist antibodies have hindered their clinical development. Here, we aimed to study the immune-related adverse events of repeated do...

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Detalles Bibliográficos
Autores principales:	Kim, Seon-Hee, Singh, Rohit, Han, Chungyong, Cho, Eunjung, Kim, Yu I., Lee, Don G., Kim, Young H., Kim, Sang Soo, Shin, Dong Hoon, You, Hye Jin, Lee, Hyeon-Woo, Kwon, Byoung S., Choi, Beom K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322392/ https://www.ncbi.nlm.nih.gov/pubmed/32868911 http://dx.doi.org/10.1038/s41423-020-00533-3

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