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Unveiling the Sugary Secrets of Plasmodium Parasites
Plasmodium parasites cause malaria disease, one of the leading global health burdens for humanity, infecting hundreds of millions of people each year. Different glycans on the parasite and the host cell surface play significant roles in both malaria pathogenesis and host defense mechanisms. So far,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322443/ https://www.ncbi.nlm.nih.gov/pubmed/34335547 http://dx.doi.org/10.3389/fmicb.2021.712538 |
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author | Goerdeler, Felix Seeberger, Peter H. Moscovitz, Oren |
author_facet | Goerdeler, Felix Seeberger, Peter H. Moscovitz, Oren |
author_sort | Goerdeler, Felix |
collection | PubMed |
description | Plasmodium parasites cause malaria disease, one of the leading global health burdens for humanity, infecting hundreds of millions of people each year. Different glycans on the parasite and the host cell surface play significant roles in both malaria pathogenesis and host defense mechanisms. So far, only small, truncated N- and O-glycans have been identified in Plasmodium species. In contrast, complex glycosylphosphatidylinositol (GPI) glycolipids are highly abundant on the parasite’s cell membrane and are essential for its survival. Moreover, the parasites express lectins that bind and exploit the host cell surface glycans for different aspects of the parasite life cycle, such as adherence, invasion, and evasion of the host immune system. In parallel, the host cell glycocalyx and lectin expression serve as the first line of defense against Plasmodium parasites and directly dictate susceptibility to Plasmodium infection. This review provides an overview of the glycobiology involved in Plasmodium-host interactions and its contribution to malaria pathogenesis. Recent findings are presented and evaluated in the context of potential therapeutic exploitation. |
format | Online Article Text |
id | pubmed-8322443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83224432021-07-31 Unveiling the Sugary Secrets of Plasmodium Parasites Goerdeler, Felix Seeberger, Peter H. Moscovitz, Oren Front Microbiol Microbiology Plasmodium parasites cause malaria disease, one of the leading global health burdens for humanity, infecting hundreds of millions of people each year. Different glycans on the parasite and the host cell surface play significant roles in both malaria pathogenesis and host defense mechanisms. So far, only small, truncated N- and O-glycans have been identified in Plasmodium species. In contrast, complex glycosylphosphatidylinositol (GPI) glycolipids are highly abundant on the parasite’s cell membrane and are essential for its survival. Moreover, the parasites express lectins that bind and exploit the host cell surface glycans for different aspects of the parasite life cycle, such as adherence, invasion, and evasion of the host immune system. In parallel, the host cell glycocalyx and lectin expression serve as the first line of defense against Plasmodium parasites and directly dictate susceptibility to Plasmodium infection. This review provides an overview of the glycobiology involved in Plasmodium-host interactions and its contribution to malaria pathogenesis. Recent findings are presented and evaluated in the context of potential therapeutic exploitation. Frontiers Media S.A. 2021-07-16 /pmc/articles/PMC8322443/ /pubmed/34335547 http://dx.doi.org/10.3389/fmicb.2021.712538 Text en Copyright © 2021 Goerdeler, Seeberger and Moscovitz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Goerdeler, Felix Seeberger, Peter H. Moscovitz, Oren Unveiling the Sugary Secrets of Plasmodium Parasites |
title | Unveiling the Sugary Secrets of Plasmodium Parasites |
title_full | Unveiling the Sugary Secrets of Plasmodium Parasites |
title_fullStr | Unveiling the Sugary Secrets of Plasmodium Parasites |
title_full_unstemmed | Unveiling the Sugary Secrets of Plasmodium Parasites |
title_short | Unveiling the Sugary Secrets of Plasmodium Parasites |
title_sort | unveiling the sugary secrets of plasmodium parasites |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322443/ https://www.ncbi.nlm.nih.gov/pubmed/34335547 http://dx.doi.org/10.3389/fmicb.2021.712538 |
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