Detection of circulating tumor DNA without a tumor-informed search using next-generation sequencing is a prognostic biomarker in pancreatic ductal adenocarcinoma

The confounding effects of next-generation sequencing (NGS) noise on detection of low frequency circulating tumor DNA (ctDNA) without a priori knowledge of solid tumor mutations has limited the applications of circulating cell-free DNA (ccfDNA) in clinical oncology. Here, we use a 118 gene panel and...

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Detalles Bibliográficos
Autores principales: Affolter, Kajsa E., Hellwig, Sabine, Nix, David A., Bronner, Mary P., Thomas, Alun, Fuertes, Carrie L., Hamil, Cindy L., Garrido-Laguna, Ignacio, Scaife, Courtney L., Mulvihill, Sean J., Underhill, Hunter R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322473/
https://www.ncbi.nlm.nih.gov/pubmed/34298235
http://dx.doi.org/10.1016/j.neo.2021.06.005

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