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Relationship between statins and the risk of amyotrophic lateral sclerosis: A PRISMA-compliant meta-analysis

OBJECTIVE: Previous studies on overlapping surveillance databases have suggested that statin use was associated with the development of amyotrophic lateral sclerosis (ALS)-like syndrome. However, the association between statin use and ALS incidence has not been clearly elucidated. To further explore...

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Autores principales: Chang, Min Cheol, Kwak, Sang Gyu, Park, Jin-Sung, Park, Donghwi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322535/
https://www.ncbi.nlm.nih.gov/pubmed/34397718
http://dx.doi.org/10.1097/MD.0000000000026751
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author Chang, Min Cheol
Kwak, Sang Gyu
Park, Jin-Sung
Park, Donghwi
author_facet Chang, Min Cheol
Kwak, Sang Gyu
Park, Jin-Sung
Park, Donghwi
author_sort Chang, Min Cheol
collection PubMed
description OBJECTIVE: Previous studies on overlapping surveillance databases have suggested that statin use was associated with the development of amyotrophic lateral sclerosis (ALS)-like syndrome. However, the association between statin use and ALS incidence has not been clearly elucidated. To further explore this issue, we performed a systemic review and meta-analysis of all available clinical studies on the association between statin use and ALS incidence. METHODS: A comprehensive database search on PubMed, Embase, Cochrane Library, and SCOPUS was conducted. We included studies up to January 31, 2020 that fulfilled our inclusion and exclusion criteria. Statin use between the ALS and control groups was collected for the meta-analysis. RESULTS: Three case-control studies and 1 cohort study, that related the risk of ALS to statin use, satisfied the inclusion criteria for the meta-analysis. There was no statistically significant difference in statin use between the ALS and control groups (odds ratio, 0.75 [95% confidence interval, 0.53–1.08]). CONCLUSION: No definite association was found between statin use and the development of ALS. Further large-scale prospective randomized control studies are necessary to draw definite conclusions.
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spelling pubmed-83225352021-08-02 Relationship between statins and the risk of amyotrophic lateral sclerosis: A PRISMA-compliant meta-analysis Chang, Min Cheol Kwak, Sang Gyu Park, Jin-Sung Park, Donghwi Medicine (Baltimore) 5300 OBJECTIVE: Previous studies on overlapping surveillance databases have suggested that statin use was associated with the development of amyotrophic lateral sclerosis (ALS)-like syndrome. However, the association between statin use and ALS incidence has not been clearly elucidated. To further explore this issue, we performed a systemic review and meta-analysis of all available clinical studies on the association between statin use and ALS incidence. METHODS: A comprehensive database search on PubMed, Embase, Cochrane Library, and SCOPUS was conducted. We included studies up to January 31, 2020 that fulfilled our inclusion and exclusion criteria. Statin use between the ALS and control groups was collected for the meta-analysis. RESULTS: Three case-control studies and 1 cohort study, that related the risk of ALS to statin use, satisfied the inclusion criteria for the meta-analysis. There was no statistically significant difference in statin use between the ALS and control groups (odds ratio, 0.75 [95% confidence interval, 0.53–1.08]). CONCLUSION: No definite association was found between statin use and the development of ALS. Further large-scale prospective randomized control studies are necessary to draw definite conclusions. Lippincott Williams & Wilkins 2021-07-30 /pmc/articles/PMC8322535/ /pubmed/34397718 http://dx.doi.org/10.1097/MD.0000000000026751 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 5300
Chang, Min Cheol
Kwak, Sang Gyu
Park, Jin-Sung
Park, Donghwi
Relationship between statins and the risk of amyotrophic lateral sclerosis: A PRISMA-compliant meta-analysis
title Relationship between statins and the risk of amyotrophic lateral sclerosis: A PRISMA-compliant meta-analysis
title_full Relationship between statins and the risk of amyotrophic lateral sclerosis: A PRISMA-compliant meta-analysis
title_fullStr Relationship between statins and the risk of amyotrophic lateral sclerosis: A PRISMA-compliant meta-analysis
title_full_unstemmed Relationship between statins and the risk of amyotrophic lateral sclerosis: A PRISMA-compliant meta-analysis
title_short Relationship between statins and the risk of amyotrophic lateral sclerosis: A PRISMA-compliant meta-analysis
title_sort relationship between statins and the risk of amyotrophic lateral sclerosis: a prisma-compliant meta-analysis
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322535/
https://www.ncbi.nlm.nih.gov/pubmed/34397718
http://dx.doi.org/10.1097/MD.0000000000026751
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