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Adapting Protocols or Models for Use in Insulin-Requiring Diabetes and Islet Transplant Recipients

The authors’ perspective is described regarding modifications made in their clinic to glucose challenge protocols and mathematical models in order to estimate insulin secretion, insulin sensitivity and glucose effectiveness in patients living with Insulin-Requiring Diabetes and patients who received...

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Autores principales: Ward, Glenn M., Walters, Jacqueline M., Gooley, Judith L., Boston, Raymond C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322616/
https://www.ncbi.nlm.nih.gov/pubmed/34335462
http://dx.doi.org/10.3389/fendo.2021.611512
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author Ward, Glenn M.
Walters, Jacqueline M.
Gooley, Judith L.
Boston, Raymond C.
author_facet Ward, Glenn M.
Walters, Jacqueline M.
Gooley, Judith L.
Boston, Raymond C.
author_sort Ward, Glenn M.
collection PubMed
description The authors’ perspective is described regarding modifications made in their clinic to glucose challenge protocols and mathematical models in order to estimate insulin secretion, insulin sensitivity and glucose effectiveness in patients living with Insulin-Requiring Diabetes and patients who received Pancreatic Islet Transplants to treat Type I diabetes (T1D) with Impaired Awareness of Hypoglycemia. The evolutions are described of protocols and models for use in T1D, and Insulin-Requiring Type 2 Diabetes (T2D) that were the basis for studies in the Islet Recipients. In each group, the need for modifications, and how the protocols and models were adapted is discussed. How the ongoing application of the adaptations is clarifying the Islet pathophysiology in the Islet Transplant Recipients is outlined.
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spelling pubmed-83226162021-07-31 Adapting Protocols or Models for Use in Insulin-Requiring Diabetes and Islet Transplant Recipients Ward, Glenn M. Walters, Jacqueline M. Gooley, Judith L. Boston, Raymond C. Front Endocrinol (Lausanne) Endocrinology The authors’ perspective is described regarding modifications made in their clinic to glucose challenge protocols and mathematical models in order to estimate insulin secretion, insulin sensitivity and glucose effectiveness in patients living with Insulin-Requiring Diabetes and patients who received Pancreatic Islet Transplants to treat Type I diabetes (T1D) with Impaired Awareness of Hypoglycemia. The evolutions are described of protocols and models for use in T1D, and Insulin-Requiring Type 2 Diabetes (T2D) that were the basis for studies in the Islet Recipients. In each group, the need for modifications, and how the protocols and models were adapted is discussed. How the ongoing application of the adaptations is clarifying the Islet pathophysiology in the Islet Transplant Recipients is outlined. Frontiers Media S.A. 2021-07-16 /pmc/articles/PMC8322616/ /pubmed/34335462 http://dx.doi.org/10.3389/fendo.2021.611512 Text en Copyright © 2021 Ward, Walters, Gooley and Boston https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Ward, Glenn M.
Walters, Jacqueline M.
Gooley, Judith L.
Boston, Raymond C.
Adapting Protocols or Models for Use in Insulin-Requiring Diabetes and Islet Transplant Recipients
title Adapting Protocols or Models for Use in Insulin-Requiring Diabetes and Islet Transplant Recipients
title_full Adapting Protocols or Models for Use in Insulin-Requiring Diabetes and Islet Transplant Recipients
title_fullStr Adapting Protocols or Models for Use in Insulin-Requiring Diabetes and Islet Transplant Recipients
title_full_unstemmed Adapting Protocols or Models for Use in Insulin-Requiring Diabetes and Islet Transplant Recipients
title_short Adapting Protocols or Models for Use in Insulin-Requiring Diabetes and Islet Transplant Recipients
title_sort adapting protocols or models for use in insulin-requiring diabetes and islet transplant recipients
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322616/
https://www.ncbi.nlm.nih.gov/pubmed/34335462
http://dx.doi.org/10.3389/fendo.2021.611512
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