Cargando…
Assocation Between Leber's Hereditary Optic Neuropathy and MT-ND1 3460G>A Mutation-Induced Alterations in Mitochondrial Function, Apoptosis, and Mitophagy
PURPOSE: To investigate the molecular mechanism underlying the Leber's hereditary optic neuropathy (LHON)-linked MT-ND1 3460G>A mutation. METHODS: Cybrid cell models were generated by fusing mitochondrial DNA-less ρ(0) cells with enucleated cells from a patient carrying the m.3460G>A muta...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322717/ https://www.ncbi.nlm.nih.gov/pubmed/34311469 http://dx.doi.org/10.1167/iovs.62.9.38 |