Assocation Between Leber's Hereditary Optic Neuropathy and MT-ND1 3460G>A Mutation-Induced Alterations in Mitochondrial Function, Apoptosis, and Mitophagy

PURPOSE: To investigate the molecular mechanism underlying the Leber's hereditary optic neuropathy (LHON)-linked MT-ND1 3460G>A mutation. METHODS: Cybrid cell models were generated by fusing mitochondrial DNA-less ρ(0) cells with enucleated cells from a patient carrying the m.3460G>A muta...

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Detalles Bibliográficos
Autores principales: Zhang, Juanjuan, Ji, Yanchun, Chen, Jie, Xu, Man, Wang, Guoping, Ci, Xiaorui, Lin, Bing, Mo, Jun Q., Zhou, Xiangtian, Guan, Min-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
Biochemistry and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322717/
https://www.ncbi.nlm.nih.gov/pubmed/34311469
http://dx.doi.org/10.1167/iovs.62.9.38

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