Cargando…

Current Strategies for Microbubble-Based Thrombus Targeting: Activation-Specific Epitopes and Small Molecular Ligands

Microbubbles with enhanced ultrasound represent a potentially potent evolution to the administration of a free drug in the treatment of thrombotic diseases. Conformational and expressional changes of several thrombotic biological components during active coagulation provide epitopes that allow site-...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Zhaojian, Huang, Huaigu, Chen, Yuexin, Zheng, Yuehong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322734/
https://www.ncbi.nlm.nih.gov/pubmed/34336810
http://dx.doi.org/10.3389/fbioe.2021.699450
_version_ 1783731117393707008
author Wang, Zhaojian
Huang, Huaigu
Chen, Yuexin
Zheng, Yuehong
author_facet Wang, Zhaojian
Huang, Huaigu
Chen, Yuexin
Zheng, Yuehong
author_sort Wang, Zhaojian
collection PubMed
description Microbubbles with enhanced ultrasound represent a potentially potent evolution to the administration of a free drug in the treatment of thrombotic diseases. Conformational and expressional changes of several thrombotic biological components during active coagulation provide epitopes that allow site-specific delivery of microbubble-based agents to the thrombus for theranostic purpose. Through the interaction with these epitopes, emerging high-affinity small molecular ligands are able to selectively target the thrombi with tremendous advantages over traditional antibody-based strategy. In this mini-review, we summarize recent novel strategies for microbubble-based targeting of thrombus through epitopes located at activated platelets and fibrin. We also discuss the challenges of current targeting modalities and supramolecular carrier systems for their translational use in thrombotic pathologies.
format Online
Article
Text
id pubmed-8322734
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-83227342021-07-31 Current Strategies for Microbubble-Based Thrombus Targeting: Activation-Specific Epitopes and Small Molecular Ligands Wang, Zhaojian Huang, Huaigu Chen, Yuexin Zheng, Yuehong Front Bioeng Biotechnol Bioengineering and Biotechnology Microbubbles with enhanced ultrasound represent a potentially potent evolution to the administration of a free drug in the treatment of thrombotic diseases. Conformational and expressional changes of several thrombotic biological components during active coagulation provide epitopes that allow site-specific delivery of microbubble-based agents to the thrombus for theranostic purpose. Through the interaction with these epitopes, emerging high-affinity small molecular ligands are able to selectively target the thrombi with tremendous advantages over traditional antibody-based strategy. In this mini-review, we summarize recent novel strategies for microbubble-based targeting of thrombus through epitopes located at activated platelets and fibrin. We also discuss the challenges of current targeting modalities and supramolecular carrier systems for their translational use in thrombotic pathologies. Frontiers Media S.A. 2021-07-16 /pmc/articles/PMC8322734/ /pubmed/34336810 http://dx.doi.org/10.3389/fbioe.2021.699450 Text en Copyright © 2021 Wang, Huang, Chen and Zheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Wang, Zhaojian
Huang, Huaigu
Chen, Yuexin
Zheng, Yuehong
Current Strategies for Microbubble-Based Thrombus Targeting: Activation-Specific Epitopes and Small Molecular Ligands
title Current Strategies for Microbubble-Based Thrombus Targeting: Activation-Specific Epitopes and Small Molecular Ligands
title_full Current Strategies for Microbubble-Based Thrombus Targeting: Activation-Specific Epitopes and Small Molecular Ligands
title_fullStr Current Strategies for Microbubble-Based Thrombus Targeting: Activation-Specific Epitopes and Small Molecular Ligands
title_full_unstemmed Current Strategies for Microbubble-Based Thrombus Targeting: Activation-Specific Epitopes and Small Molecular Ligands
title_short Current Strategies for Microbubble-Based Thrombus Targeting: Activation-Specific Epitopes and Small Molecular Ligands
title_sort current strategies for microbubble-based thrombus targeting: activation-specific epitopes and small molecular ligands
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322734/
https://www.ncbi.nlm.nih.gov/pubmed/34336810
http://dx.doi.org/10.3389/fbioe.2021.699450
work_keys_str_mv AT wangzhaojian currentstrategiesformicrobubblebasedthrombustargetingactivationspecificepitopesandsmallmolecularligands
AT huanghuaigu currentstrategiesformicrobubblebasedthrombustargetingactivationspecificepitopesandsmallmolecularligands
AT chenyuexin currentstrategiesformicrobubblebasedthrombustargetingactivationspecificepitopesandsmallmolecularligands
AT zhengyuehong currentstrategiesformicrobubblebasedthrombustargetingactivationspecificepitopesandsmallmolecularligands