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Phase I Study to Assess Safety of Laser-Assisted Topical Administration of an Anti-TNF Biologic in Patients With Chronic Plaque-Type Psoriasis
Ablative fractional laser treatment facilitates epidermal drug delivery, which might be an interesting option to increase the topical efficacy of biological drugs in a variety of dermatological diseases. This work aims at investigating safety and tolerability of this new treatment approach in patien...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322842/ https://www.ncbi.nlm.nih.gov/pubmed/34336906 http://dx.doi.org/10.3389/fmed.2021.712511 |
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author | Bauer, Martin Lackner, Edith Matzneller, Peter Al Jalali, Valentin Pajenda, Sahra Ling, Vincent Böhler, Christof Braun, Werner Braun, Reinhard Boesch, Maximilian Brunner, Patrick M. Zeitlinger, Markus |
author_facet | Bauer, Martin Lackner, Edith Matzneller, Peter Al Jalali, Valentin Pajenda, Sahra Ling, Vincent Böhler, Christof Braun, Werner Braun, Reinhard Boesch, Maximilian Brunner, Patrick M. Zeitlinger, Markus |
author_sort | Bauer, Martin |
collection | PubMed |
description | Ablative fractional laser treatment facilitates epidermal drug delivery, which might be an interesting option to increase the topical efficacy of biological drugs in a variety of dermatological diseases. This work aims at investigating safety and tolerability of this new treatment approach in patients with plaque-type psoriasis. Eight patients with plaque-type psoriasis were enrolled in this study. All patients received (i) ablative fractional laser microporation (AFL) of a psoriatic lesion with an Er:YAG laser + etanercept (ETA; Enbrel® solution for injection) (AFL-ETA), (ii) ETA alone on another lesion, and, if feasible, (iii) AFL alone on an additional lesion. Overall, all treatment arms showed a favorable safety profile. AFL-ETA improved the lesion-specific TPSS score by 1.75 vs. baseline, whereas ETA or AFL alone showed a TPSS score improvement of 0.75 points, a difference that was not statistically significant and might be attributable to differences in baseline scores. Topical administration of ETA to psoriatic plaques via AFL-generated micropores was generally well-tolerated. No special precautions seem necessary in future studies. Clinical benefit will need assessment in sufficiently powered follow-up studies. |
format | Online Article Text |
id | pubmed-8322842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83228422021-07-31 Phase I Study to Assess Safety of Laser-Assisted Topical Administration of an Anti-TNF Biologic in Patients With Chronic Plaque-Type Psoriasis Bauer, Martin Lackner, Edith Matzneller, Peter Al Jalali, Valentin Pajenda, Sahra Ling, Vincent Böhler, Christof Braun, Werner Braun, Reinhard Boesch, Maximilian Brunner, Patrick M. Zeitlinger, Markus Front Med (Lausanne) Medicine Ablative fractional laser treatment facilitates epidermal drug delivery, which might be an interesting option to increase the topical efficacy of biological drugs in a variety of dermatological diseases. This work aims at investigating safety and tolerability of this new treatment approach in patients with plaque-type psoriasis. Eight patients with plaque-type psoriasis were enrolled in this study. All patients received (i) ablative fractional laser microporation (AFL) of a psoriatic lesion with an Er:YAG laser + etanercept (ETA; Enbrel® solution for injection) (AFL-ETA), (ii) ETA alone on another lesion, and, if feasible, (iii) AFL alone on an additional lesion. Overall, all treatment arms showed a favorable safety profile. AFL-ETA improved the lesion-specific TPSS score by 1.75 vs. baseline, whereas ETA or AFL alone showed a TPSS score improvement of 0.75 points, a difference that was not statistically significant and might be attributable to differences in baseline scores. Topical administration of ETA to psoriatic plaques via AFL-generated micropores was generally well-tolerated. No special precautions seem necessary in future studies. Clinical benefit will need assessment in sufficiently powered follow-up studies. Frontiers Media S.A. 2021-07-16 /pmc/articles/PMC8322842/ /pubmed/34336906 http://dx.doi.org/10.3389/fmed.2021.712511 Text en Copyright © 2021 Bauer, Lackner, Matzneller, Al Jalali, Pajenda, Ling, Böhler, Braun, Braun, Boesch, Brunner and Zeitlinger. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Bauer, Martin Lackner, Edith Matzneller, Peter Al Jalali, Valentin Pajenda, Sahra Ling, Vincent Böhler, Christof Braun, Werner Braun, Reinhard Boesch, Maximilian Brunner, Patrick M. Zeitlinger, Markus Phase I Study to Assess Safety of Laser-Assisted Topical Administration of an Anti-TNF Biologic in Patients With Chronic Plaque-Type Psoriasis |
title | Phase I Study to Assess Safety of Laser-Assisted Topical Administration of an Anti-TNF Biologic in Patients With Chronic Plaque-Type Psoriasis |
title_full | Phase I Study to Assess Safety of Laser-Assisted Topical Administration of an Anti-TNF Biologic in Patients With Chronic Plaque-Type Psoriasis |
title_fullStr | Phase I Study to Assess Safety of Laser-Assisted Topical Administration of an Anti-TNF Biologic in Patients With Chronic Plaque-Type Psoriasis |
title_full_unstemmed | Phase I Study to Assess Safety of Laser-Assisted Topical Administration of an Anti-TNF Biologic in Patients With Chronic Plaque-Type Psoriasis |
title_short | Phase I Study to Assess Safety of Laser-Assisted Topical Administration of an Anti-TNF Biologic in Patients With Chronic Plaque-Type Psoriasis |
title_sort | phase i study to assess safety of laser-assisted topical administration of an anti-tnf biologic in patients with chronic plaque-type psoriasis |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322842/ https://www.ncbi.nlm.nih.gov/pubmed/34336906 http://dx.doi.org/10.3389/fmed.2021.712511 |
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