Cargando…
Shifting landscapes of human MTHFR missense-variant effects
Most rare clinical missense variants cannot currently be classified as pathogenic or benign. Deficiency in human 5,10-methylenetetrahydrofolate reductase (MTHFR), the most common inherited disorder of folate metabolism, is caused primarily by rare missense variants. Further complicating variant inte...
Autores principales: | Weile, Jochen, Kishore, Nishka, Sun, Song, Maaieh, Ranim, Verby, Marta, Li, Roujia, Fotiadou, Iosifina, Kitaygorodsky, Julia, Wu, Yingzhou, Holenstein, Alexander, Bürer, Céline, Blomgren, Linnea, Yang, Shan, Nussbaum, Robert, Rozen, Rima, Watkins, David, Gebbia, Marinella, Kozich, Viktor, Garton, Michael, Froese, D. Sean, Roth, Frederick P. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322931/ https://www.ncbi.nlm.nih.gov/pubmed/34214447 http://dx.doi.org/10.1016/j.ajhg.2021.05.009 |
Ejemplares similares
-
A proactive genotype-to-patient-phenotype map for cystathionine beta-synthase
por: Sun, Song, et al.
Publicado: (2020) -
Improved pathogenicity prediction for rare human missense variants
por: Wu, Yingzhou, et al.
Publicado: (2021) -
Improved pathogenicity prediction for rare human missense variants
por: Wu, Yingzhou, et al.
Publicado: (2021) -
A web application and service for imputing and visualizing missense variant effect maps
por: Wu, Yingzhou, et al.
Publicado: (2019) -
Systematically testing human HMBS missense variants to reveal mechanism and pathogenic variation
por: van Loggerenberg, Warren, et al.
Publicado: (2023)