Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells

RNA-binding protein 24 (RBM24) has been shown to play tumor-suppressive functions in various types of cancer. The present study aimed to investigate the role of RBM24 in liver cancers and its downstream mechanisms. The present study demonstrated that RBM24 functioned as a tumor suppressor in liver c...

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Autores principales: Moon, Sung Ung, Kim, Jang Hyun, Woo, Hyun Goo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323002/
https://www.ncbi.nlm.nih.gov/pubmed/34345299
http://dx.doi.org/10.3892/ol.2021.12935
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author Moon, Sung Ung
Kim, Jang Hyun
Woo, Hyun Goo
author_facet Moon, Sung Ung
Kim, Jang Hyun
Woo, Hyun Goo
author_sort Moon, Sung Ung
collection PubMed
description RNA-binding protein 24 (RBM24) has been shown to play tumor-suppressive functions in various types of cancer. The present study aimed to investigate the role of RBM24 in liver cancers and its downstream mechanisms. The present study demonstrated that RBM24 functioned as a tumor suppressor in liver cancer cells, and inhibited nuclear translocation of β-catenin and tumor protein 63 expression by immunocytochemistry. In addition, RBM24 could suppress sphere formation in a multicellular tumor spheroid model of liver cancer cells. In conclusion, it is hypothesized that RBM24 is a tumor suppressor of liver cancer cells, which could be a potential novel therapeutic target for treatment of patients with liver cancer.
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spelling pubmed-83230022021-08-02 Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells Moon, Sung Ung Kim, Jang Hyun Woo, Hyun Goo Oncol Lett Articles RNA-binding protein 24 (RBM24) has been shown to play tumor-suppressive functions in various types of cancer. The present study aimed to investigate the role of RBM24 in liver cancers and its downstream mechanisms. The present study demonstrated that RBM24 functioned as a tumor suppressor in liver cancer cells, and inhibited nuclear translocation of β-catenin and tumor protein 63 expression by immunocytochemistry. In addition, RBM24 could suppress sphere formation in a multicellular tumor spheroid model of liver cancer cells. In conclusion, it is hypothesized that RBM24 is a tumor suppressor of liver cancer cells, which could be a potential novel therapeutic target for treatment of patients with liver cancer. D.A. Spandidos 2021-09 2021-07-19 /pmc/articles/PMC8323002/ /pubmed/34345299 http://dx.doi.org/10.3892/ol.2021.12935 Text en Copyright: © Moon et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Moon, Sung Ung
Kim, Jang Hyun
Woo, Hyun Goo
Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells
title Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells
title_full Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells
title_fullStr Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells
title_full_unstemmed Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells
title_short Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells
title_sort tumor suppressor rbm24 inhibits nuclear translocation of ctnnb1 and tp63 expression in liver cancer cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323002/
https://www.ncbi.nlm.nih.gov/pubmed/34345299
http://dx.doi.org/10.3892/ol.2021.12935
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AT woohyungoo tumorsuppressorrbm24inhibitsnucleartranslocationofctnnb1andtp63expressioninlivercancercells

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