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Correspondence between patterns of cerebral blood flow and structure in adolescents with and without bipolar disorder
Adolescence is a period of rapid development of the brain’s inherent functional and structural networks; however, little is known about the region-to-region organization of adolescent cerebral blood flow (CBF) or its relationship to neuroanatomy. Here, we investigate both the regional covariation of...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323335/ https://www.ncbi.nlm.nih.gov/pubmed/33487070 http://dx.doi.org/10.1177/0271678X21989246 |
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author | Luciw, Nicholas J Toma, Simina Goldstein, Benjamin I MacIntosh, Bradley J |
author_facet | Luciw, Nicholas J Toma, Simina Goldstein, Benjamin I MacIntosh, Bradley J |
author_sort | Luciw, Nicholas J |
collection | PubMed |
description | Adolescence is a period of rapid development of the brain’s inherent functional and structural networks; however, little is known about the region-to-region organization of adolescent cerebral blood flow (CBF) or its relationship to neuroanatomy. Here, we investigate both the regional covariation of CBF MRI and the covariation of structural MRI, in adolescents with and without bipolar disorder. Bipolar disorder is a disease with increased onset during adolescence, putative vascular underpinnings, and evidence of anomalous CBF and brain structure. In both groups, through hierarchical clustering, we found CBF covariance was principally described by clusters of regions circumscribed to the left hemisphere, right hemisphere, and the inferior brain; these clusters were spatially reminiscent of cerebral vascular territories. CBF covariance was associated with structural covariance in both the healthy group (n = 56; r = 0.20, p < 0.0001) and in the bipolar disorder group (n = 68; r = 0.36, p < 0.0001), and this CBF-structure correspondence was higher in bipolar disorder (p = 0.0028). There was lower CBF covariance in bipolar disorder compared to controls between the left angular gyrus and pre- and post-central gyri. Altogether, CBF covariance revealed distinct brain organization, had modest correspondence to structural covariance, and revealed evidence of differences in bipolar disorder. |
format | Online Article Text |
id | pubmed-8323335 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-83233352021-08-09 Correspondence between patterns of cerebral blood flow and structure in adolescents with and without bipolar disorder Luciw, Nicholas J Toma, Simina Goldstein, Benjamin I MacIntosh, Bradley J J Cereb Blood Flow Metab Original Articles Adolescence is a period of rapid development of the brain’s inherent functional and structural networks; however, little is known about the region-to-region organization of adolescent cerebral blood flow (CBF) or its relationship to neuroanatomy. Here, we investigate both the regional covariation of CBF MRI and the covariation of structural MRI, in adolescents with and without bipolar disorder. Bipolar disorder is a disease with increased onset during adolescence, putative vascular underpinnings, and evidence of anomalous CBF and brain structure. In both groups, through hierarchical clustering, we found CBF covariance was principally described by clusters of regions circumscribed to the left hemisphere, right hemisphere, and the inferior brain; these clusters were spatially reminiscent of cerebral vascular territories. CBF covariance was associated with structural covariance in both the healthy group (n = 56; r = 0.20, p < 0.0001) and in the bipolar disorder group (n = 68; r = 0.36, p < 0.0001), and this CBF-structure correspondence was higher in bipolar disorder (p = 0.0028). There was lower CBF covariance in bipolar disorder compared to controls between the left angular gyrus and pre- and post-central gyri. Altogether, CBF covariance revealed distinct brain organization, had modest correspondence to structural covariance, and revealed evidence of differences in bipolar disorder. SAGE Publications 2021-01-24 2021-08 /pmc/articles/PMC8323335/ /pubmed/33487070 http://dx.doi.org/10.1177/0271678X21989246 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Articles Luciw, Nicholas J Toma, Simina Goldstein, Benjamin I MacIntosh, Bradley J Correspondence between patterns of cerebral blood flow and structure in adolescents with and without bipolar disorder |
title | Correspondence between patterns of cerebral blood flow and structure in adolescents with and without bipolar disorder |
title_full | Correspondence between patterns of cerebral blood flow and structure in adolescents with and without bipolar disorder |
title_fullStr | Correspondence between patterns of cerebral blood flow and structure in adolescents with and without bipolar disorder |
title_full_unstemmed | Correspondence between patterns of cerebral blood flow and structure in adolescents with and without bipolar disorder |
title_short | Correspondence between patterns of cerebral blood flow and structure in adolescents with and without bipolar disorder |
title_sort | correspondence between patterns of cerebral blood flow and structure in adolescents with and without bipolar disorder |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323335/ https://www.ncbi.nlm.nih.gov/pubmed/33487070 http://dx.doi.org/10.1177/0271678X21989246 |
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