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Preliminary results of clinical use of colchicine in COVID-19 treatment
We report a case of the use of colchicine in a patient infected with SARS-CoV-2 virus. A 37-year-old man with COVID-19 presented with moderate symptoms, mild pulmonary impairment and elevated inflammatory markers, suggesting an increased risk of cytokine storm and possible worsening of clinical cond...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323388/ https://www.ncbi.nlm.nih.gov/pubmed/34326122 http://dx.doi.org/10.1136/bcr-2021-244482 |
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author | Knack, Rafael Silvestre Losso, Luis Carlos Knack, Renata Silvestre Hanada, Talie |
author_facet | Knack, Rafael Silvestre Losso, Luis Carlos Knack, Renata Silvestre Hanada, Talie |
author_sort | Knack, Rafael Silvestre |
collection | PubMed |
description | We report a case of the use of colchicine in a patient infected with SARS-CoV-2 virus. A 37-year-old man with COVID-19 presented with moderate symptoms, mild pulmonary impairment and elevated inflammatory markers, suggesting an increased risk of cytokine storm and possible worsening of clinical condition. Experimental use of colchicine resulted in an 85% decrease in C reactive protein levels 3 days after treatment initiation and a 182.6% decrease in interleukin-6 levels 8 days after treatment initiation. Due to the lack of effective therapies, it is important to search for potential compounds and compounds that focus on controlling the danger caused by systemic inflammation in COVID-19. Although further research is needed in the area of colchicine and viral infection, preliminary efficacy was observed. |
format | Online Article Text |
id | pubmed-8323388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-83233882021-08-19 Preliminary results of clinical use of colchicine in COVID-19 treatment Knack, Rafael Silvestre Losso, Luis Carlos Knack, Renata Silvestre Hanada, Talie BMJ Case Rep Case Report We report a case of the use of colchicine in a patient infected with SARS-CoV-2 virus. A 37-year-old man with COVID-19 presented with moderate symptoms, mild pulmonary impairment and elevated inflammatory markers, suggesting an increased risk of cytokine storm and possible worsening of clinical condition. Experimental use of colchicine resulted in an 85% decrease in C reactive protein levels 3 days after treatment initiation and a 182.6% decrease in interleukin-6 levels 8 days after treatment initiation. Due to the lack of effective therapies, it is important to search for potential compounds and compounds that focus on controlling the danger caused by systemic inflammation in COVID-19. Although further research is needed in the area of colchicine and viral infection, preliminary efficacy was observed. BMJ Publishing Group 2021-07-29 /pmc/articles/PMC8323388/ /pubmed/34326122 http://dx.doi.org/10.1136/bcr-2021-244482 Text en © BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ. https://bmj.com/coronavirus/usageThis article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained. |
spellingShingle | Case Report Knack, Rafael Silvestre Losso, Luis Carlos Knack, Renata Silvestre Hanada, Talie Preliminary results of clinical use of colchicine in COVID-19 treatment |
title | Preliminary results of clinical use of colchicine in COVID-19 treatment |
title_full | Preliminary results of clinical use of colchicine in COVID-19 treatment |
title_fullStr | Preliminary results of clinical use of colchicine in COVID-19 treatment |
title_full_unstemmed | Preliminary results of clinical use of colchicine in COVID-19 treatment |
title_short | Preliminary results of clinical use of colchicine in COVID-19 treatment |
title_sort | preliminary results of clinical use of colchicine in covid-19 treatment |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323388/ https://www.ncbi.nlm.nih.gov/pubmed/34326122 http://dx.doi.org/10.1136/bcr-2021-244482 |
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