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A Unique Presentation of Fahr's Syndrome Secondary to Hypoparathyroidism

Fahr's syndrome is a rare condition characterized by deposition of bilateral symmetric calcium deposits in the basal ganglia and cerebellar region, leading to neurological and psychiatric sequelae. Herein we describe a case of a 62-year-old female presented with aphasia, bilateral lower limb ri...

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Autores principales: Rashid Khan, Zaraq, Waheed, Waqar, Mabood, Jawad, Ali, Asim, Burki, Gulalai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323617/
https://www.ncbi.nlm.nih.gov/pubmed/34345548
http://dx.doi.org/10.7759/cureus.16063
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author Rashid Khan, Zaraq
Waheed, Waqar
Mabood, Jawad
Ali, Asim
Burki, Gulalai
author_facet Rashid Khan, Zaraq
Waheed, Waqar
Mabood, Jawad
Ali, Asim
Burki, Gulalai
author_sort Rashid Khan, Zaraq
collection PubMed
description Fahr's syndrome is a rare condition characterized by deposition of bilateral symmetric calcium deposits in the basal ganglia and cerebellar region, leading to neurological and psychiatric sequelae. Herein we describe a case of a 62-year-old female presented with aphasia, bilateral lower limb rigidity, tremors, and gait disturbance. Her past medical history included thyroidectomy and radiation therapy 10 years back due to papillary carcinoma of the thyroid gland. On examination, she had poor speech, resting tremor, walking difficulty, and decreased power in all limbs with rigidity. Her Chvostek and Trousseau signs were positive. Serum investigations revealed hypocalcemia and low levels of parathyroid hormone and thyroid-stimulating hormone. Brain magnetic resonance imaging revealed calcified lesions in basal ganglia, thalami, and dentate nuclei. She was diagnosed with Fahr's syndrome due to hypoparathyroidism, and she was managed with calcium gluconate, vitamin D, salt-free albumin, and levodopa-carbidopa, improving her condition. The patient was then discharged on calcium gluconate, calcitriol, recombinant parathyroid hormone, and levodopa-carbidopa with follow-up.
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spelling pubmed-83236172021-08-02 A Unique Presentation of Fahr's Syndrome Secondary to Hypoparathyroidism Rashid Khan, Zaraq Waheed, Waqar Mabood, Jawad Ali, Asim Burki, Gulalai Cureus Internal Medicine Fahr's syndrome is a rare condition characterized by deposition of bilateral symmetric calcium deposits in the basal ganglia and cerebellar region, leading to neurological and psychiatric sequelae. Herein we describe a case of a 62-year-old female presented with aphasia, bilateral lower limb rigidity, tremors, and gait disturbance. Her past medical history included thyroidectomy and radiation therapy 10 years back due to papillary carcinoma of the thyroid gland. On examination, she had poor speech, resting tremor, walking difficulty, and decreased power in all limbs with rigidity. Her Chvostek and Trousseau signs were positive. Serum investigations revealed hypocalcemia and low levels of parathyroid hormone and thyroid-stimulating hormone. Brain magnetic resonance imaging revealed calcified lesions in basal ganglia, thalami, and dentate nuclei. She was diagnosed with Fahr's syndrome due to hypoparathyroidism, and she was managed with calcium gluconate, vitamin D, salt-free albumin, and levodopa-carbidopa, improving her condition. The patient was then discharged on calcium gluconate, calcitriol, recombinant parathyroid hormone, and levodopa-carbidopa with follow-up. Cureus 2021-06-30 /pmc/articles/PMC8323617/ /pubmed/34345548 http://dx.doi.org/10.7759/cureus.16063 Text en Copyright © 2021, Rashid Khan et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Rashid Khan, Zaraq
Waheed, Waqar
Mabood, Jawad
Ali, Asim
Burki, Gulalai
A Unique Presentation of Fahr's Syndrome Secondary to Hypoparathyroidism
title A Unique Presentation of Fahr's Syndrome Secondary to Hypoparathyroidism
title_full A Unique Presentation of Fahr's Syndrome Secondary to Hypoparathyroidism
title_fullStr A Unique Presentation of Fahr's Syndrome Secondary to Hypoparathyroidism
title_full_unstemmed A Unique Presentation of Fahr's Syndrome Secondary to Hypoparathyroidism
title_short A Unique Presentation of Fahr's Syndrome Secondary to Hypoparathyroidism
title_sort unique presentation of fahr's syndrome secondary to hypoparathyroidism
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323617/
https://www.ncbi.nlm.nih.gov/pubmed/34345548
http://dx.doi.org/10.7759/cureus.16063
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