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Inflammatory Biomarkers Levels in T2DM Emirati Patients with Diabetic Neuropathy

INTRODUCTION: Previous studies have suggested the involvement of chronic low‐grade inflammation in the pathogenesis of diabetic neuropathy (DNP). However, none of these studies have examined the levels of monocyte chemoattractant protein-1 (MCP-1) in type 2 diabetes mellitus (T2DM) patients with con...

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Autores principales: Mussa, Bashair M, Srivastava, Ankita, Al-Habshi, Abeer, Mohammed, Abdul Khader, Halwani, Rabih, Abusnana, Salah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323777/
https://www.ncbi.nlm.nih.gov/pubmed/34345175
http://dx.doi.org/10.2147/DMSO.S319863
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author Mussa, Bashair M
Srivastava, Ankita
Al-Habshi, Abeer
Mohammed, Abdul Khader
Halwani, Rabih
Abusnana, Salah
author_facet Mussa, Bashair M
Srivastava, Ankita
Al-Habshi, Abeer
Mohammed, Abdul Khader
Halwani, Rabih
Abusnana, Salah
author_sort Mussa, Bashair M
collection PubMed
description INTRODUCTION: Previous studies have suggested the involvement of chronic low‐grade inflammation in the pathogenesis of diabetic neuropathy (DNP). However, none of these studies have examined the levels of monocyte chemoattractant protein-1 (MCP-1) in type 2 diabetes mellitus (T2DM) patients with confirmed diagnosis of neuropathy. Therefore, the present study aims to investigate the levels of MCP-1 along with IL-6, IL-8 and TGF-β in patients with T2DM and confirmed neuropathy and identify correlations, if any, between MCP-1 and other parameters. METHODS: A single center cross-sectional clinical study was conducted at University Hospital Sharjah (UHS) and University of Sharjah. One hundred and two patients with T2DM were recruited from diabetes clinics at UHS and were stratified into different groups based on diagnosis of DNP and other parameters. Several analyses were conducted to evaluate and compare the levels of MCP-1, IL-6, IL-8, and TGF-β across these groups of patients and identify correlations, if any, between MCP-1 and other variables. RESULTS: A significant increase was found in the levels of MCP-1 in T2DM patients with DNP compared to the patients without DNP (p=0.002, p-adj=0.007). Further analysis has shown that levels of IL-8 (p=0.008) and TGF-β (p=0.06) were increased and decreased, respectively, in patients with DNP compared to patients without DNP. Moreover, strong correlations were found between MCP-1, IL-8 and TGF-β levels. CONCLUSION: The key finding of the present study is the significant elevation in levels of MCP-1 in T2DM patients with DNP compared to the patients without DNP and IL-8 and TGF-β were strong predictors of MCP-1 increased levels.
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spelling pubmed-83237772021-08-02 Inflammatory Biomarkers Levels in T2DM Emirati Patients with Diabetic Neuropathy Mussa, Bashair M Srivastava, Ankita Al-Habshi, Abeer Mohammed, Abdul Khader Halwani, Rabih Abusnana, Salah Diabetes Metab Syndr Obes Original Research INTRODUCTION: Previous studies have suggested the involvement of chronic low‐grade inflammation in the pathogenesis of diabetic neuropathy (DNP). However, none of these studies have examined the levels of monocyte chemoattractant protein-1 (MCP-1) in type 2 diabetes mellitus (T2DM) patients with confirmed diagnosis of neuropathy. Therefore, the present study aims to investigate the levels of MCP-1 along with IL-6, IL-8 and TGF-β in patients with T2DM and confirmed neuropathy and identify correlations, if any, between MCP-1 and other parameters. METHODS: A single center cross-sectional clinical study was conducted at University Hospital Sharjah (UHS) and University of Sharjah. One hundred and two patients with T2DM were recruited from diabetes clinics at UHS and were stratified into different groups based on diagnosis of DNP and other parameters. Several analyses were conducted to evaluate and compare the levels of MCP-1, IL-6, IL-8, and TGF-β across these groups of patients and identify correlations, if any, between MCP-1 and other variables. RESULTS: A significant increase was found in the levels of MCP-1 in T2DM patients with DNP compared to the patients without DNP (p=0.002, p-adj=0.007). Further analysis has shown that levels of IL-8 (p=0.008) and TGF-β (p=0.06) were increased and decreased, respectively, in patients with DNP compared to patients without DNP. Moreover, strong correlations were found between MCP-1, IL-8 and TGF-β levels. CONCLUSION: The key finding of the present study is the significant elevation in levels of MCP-1 in T2DM patients with DNP compared to the patients without DNP and IL-8 and TGF-β were strong predictors of MCP-1 increased levels. Dove 2021-07-26 /pmc/articles/PMC8323777/ /pubmed/34345175 http://dx.doi.org/10.2147/DMSO.S319863 Text en © 2021 Mussa et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Mussa, Bashair M
Srivastava, Ankita
Al-Habshi, Abeer
Mohammed, Abdul Khader
Halwani, Rabih
Abusnana, Salah
Inflammatory Biomarkers Levels in T2DM Emirati Patients with Diabetic Neuropathy
title Inflammatory Biomarkers Levels in T2DM Emirati Patients with Diabetic Neuropathy
title_full Inflammatory Biomarkers Levels in T2DM Emirati Patients with Diabetic Neuropathy
title_fullStr Inflammatory Biomarkers Levels in T2DM Emirati Patients with Diabetic Neuropathy
title_full_unstemmed Inflammatory Biomarkers Levels in T2DM Emirati Patients with Diabetic Neuropathy
title_short Inflammatory Biomarkers Levels in T2DM Emirati Patients with Diabetic Neuropathy
title_sort inflammatory biomarkers levels in t2dm emirati patients with diabetic neuropathy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323777/
https://www.ncbi.nlm.nih.gov/pubmed/34345175
http://dx.doi.org/10.2147/DMSO.S319863
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