RNA modification of an RNA modifier prevents self-RNA sensing

A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 (ADAR1) mRNA is N6-methyladenosine (m(6)A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during the IFN response and preventing activation...

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Detalles Bibliográficos
Autores principales: Snider, Daltry L., Horner, Stacy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323910/
https://www.ncbi.nlm.nih.gov/pubmed/34329302
http://dx.doi.org/10.1371/journal.pbio.3001342
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author Snider, Daltry L.
Horner, Stacy M.
author_facet Snider, Daltry L.
Horner, Stacy M.
author_sort Snider, Daltry L.
collection PubMed
description A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 (ADAR1) mRNA is N6-methyladenosine (m(6)A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during the IFN response and preventing activation of the melanoma differentiation–associated protein 5 (MDA5)-mediated host antiviral response.
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spelling pubmed-83239102021-07-31 RNA modification of an RNA modifier prevents self-RNA sensing Snider, Daltry L. Horner, Stacy M. PLoS Biol Primer A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 (ADAR1) mRNA is N6-methyladenosine (m(6)A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during the IFN response and preventing activation of the melanoma differentiation–associated protein 5 (MDA5)-mediated host antiviral response. Public Library of Science 2021-07-30 /pmc/articles/PMC8323910/ /pubmed/34329302 http://dx.doi.org/10.1371/journal.pbio.3001342 Text en © 2021 Snider, Horner https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Primer
Snider, Daltry L.
Horner, Stacy M.
RNA modification of an RNA modifier prevents self-RNA sensing
title RNA modification of an RNA modifier prevents self-RNA sensing
title_full RNA modification of an RNA modifier prevents self-RNA sensing
title_fullStr RNA modification of an RNA modifier prevents self-RNA sensing
title_full_unstemmed RNA modification of an RNA modifier prevents self-RNA sensing
title_short RNA modification of an RNA modifier prevents self-RNA sensing
title_sort rna modification of an rna modifier prevents self-rna sensing
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323910/
https://www.ncbi.nlm.nih.gov/pubmed/34329302
http://dx.doi.org/10.1371/journal.pbio.3001342
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