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Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test

Spontaneous recognition tests, which utilize rodents’ innate tendency to explore novelty, can evaluate not only simple non-associative recognition memory but also more complex associative memory in animals. In the present study, we investigated whether the length of the object familiarization period...

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Detalles Bibliográficos
Autores principales: Shimoda, Shota, Ozawa, Takaaki, Ichitani, Yukio, Yamada, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323955/
https://www.ncbi.nlm.nih.gov/pubmed/34329332
http://dx.doi.org/10.1371/journal.pone.0254570
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author Shimoda, Shota
Ozawa, Takaaki
Ichitani, Yukio
Yamada, Kazuo
author_facet Shimoda, Shota
Ozawa, Takaaki
Ichitani, Yukio
Yamada, Kazuo
author_sort Shimoda, Shota
collection PubMed
description Spontaneous recognition tests, which utilize rodents’ innate tendency to explore novelty, can evaluate not only simple non-associative recognition memory but also more complex associative memory in animals. In the present study, we investigated whether the length of the object familiarization period (sample phase) improved subsequent novelty discrimination in the spontaneous object, place, and object-place-context (OPC) recognition tests in rats. In the OPC recognition test, rats showed a significant novelty preference only when the familiarization period was 30 min but not when it was 5 min or 15 min. In addition, repeated 30-min familiarization periods extended the significant novelty preference to 72 hours. However, the rats exhibited a successful discrimination between the stayed and replaced objects under 15 min and 30 min familiarization period conditions in the place recognition test and between the novel and familiar objects under all conditions of 5, 15 and 30 min in the object recognition test. Our results suggest that the extension of the familiarization period improves performance in the spontaneous recognition paradigms, and a longer familiarization period is necessary for long-term associative recognition memory than for non-associative memory.
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spelling pubmed-83239552021-07-31 Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test Shimoda, Shota Ozawa, Takaaki Ichitani, Yukio Yamada, Kazuo PLoS One Research Article Spontaneous recognition tests, which utilize rodents’ innate tendency to explore novelty, can evaluate not only simple non-associative recognition memory but also more complex associative memory in animals. In the present study, we investigated whether the length of the object familiarization period (sample phase) improved subsequent novelty discrimination in the spontaneous object, place, and object-place-context (OPC) recognition tests in rats. In the OPC recognition test, rats showed a significant novelty preference only when the familiarization period was 30 min but not when it was 5 min or 15 min. In addition, repeated 30-min familiarization periods extended the significant novelty preference to 72 hours. However, the rats exhibited a successful discrimination between the stayed and replaced objects under 15 min and 30 min familiarization period conditions in the place recognition test and between the novel and familiar objects under all conditions of 5, 15 and 30 min in the object recognition test. Our results suggest that the extension of the familiarization period improves performance in the spontaneous recognition paradigms, and a longer familiarization period is necessary for long-term associative recognition memory than for non-associative memory. Public Library of Science 2021-07-30 /pmc/articles/PMC8323955/ /pubmed/34329332 http://dx.doi.org/10.1371/journal.pone.0254570 Text en © 2021 Shimoda et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Shimoda, Shota
Ozawa, Takaaki
Ichitani, Yukio
Yamada, Kazuo
Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test
title Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test
title_full Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test
title_fullStr Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test
title_full_unstemmed Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test
title_short Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test
title_sort long-term associative memory in rats: effects of familiarization period in object-place-context recognition test
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323955/
https://www.ncbi.nlm.nih.gov/pubmed/34329332
http://dx.doi.org/10.1371/journal.pone.0254570
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