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Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test
Spontaneous recognition tests, which utilize rodents’ innate tendency to explore novelty, can evaluate not only simple non-associative recognition memory but also more complex associative memory in animals. In the present study, we investigated whether the length of the object familiarization period...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323955/ https://www.ncbi.nlm.nih.gov/pubmed/34329332 http://dx.doi.org/10.1371/journal.pone.0254570 |
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author | Shimoda, Shota Ozawa, Takaaki Ichitani, Yukio Yamada, Kazuo |
author_facet | Shimoda, Shota Ozawa, Takaaki Ichitani, Yukio Yamada, Kazuo |
author_sort | Shimoda, Shota |
collection | PubMed |
description | Spontaneous recognition tests, which utilize rodents’ innate tendency to explore novelty, can evaluate not only simple non-associative recognition memory but also more complex associative memory in animals. In the present study, we investigated whether the length of the object familiarization period (sample phase) improved subsequent novelty discrimination in the spontaneous object, place, and object-place-context (OPC) recognition tests in rats. In the OPC recognition test, rats showed a significant novelty preference only when the familiarization period was 30 min but not when it was 5 min or 15 min. In addition, repeated 30-min familiarization periods extended the significant novelty preference to 72 hours. However, the rats exhibited a successful discrimination between the stayed and replaced objects under 15 min and 30 min familiarization period conditions in the place recognition test and between the novel and familiar objects under all conditions of 5, 15 and 30 min in the object recognition test. Our results suggest that the extension of the familiarization period improves performance in the spontaneous recognition paradigms, and a longer familiarization period is necessary for long-term associative recognition memory than for non-associative memory. |
format | Online Article Text |
id | pubmed-8323955 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-83239552021-07-31 Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test Shimoda, Shota Ozawa, Takaaki Ichitani, Yukio Yamada, Kazuo PLoS One Research Article Spontaneous recognition tests, which utilize rodents’ innate tendency to explore novelty, can evaluate not only simple non-associative recognition memory but also more complex associative memory in animals. In the present study, we investigated whether the length of the object familiarization period (sample phase) improved subsequent novelty discrimination in the spontaneous object, place, and object-place-context (OPC) recognition tests in rats. In the OPC recognition test, rats showed a significant novelty preference only when the familiarization period was 30 min but not when it was 5 min or 15 min. In addition, repeated 30-min familiarization periods extended the significant novelty preference to 72 hours. However, the rats exhibited a successful discrimination between the stayed and replaced objects under 15 min and 30 min familiarization period conditions in the place recognition test and between the novel and familiar objects under all conditions of 5, 15 and 30 min in the object recognition test. Our results suggest that the extension of the familiarization period improves performance in the spontaneous recognition paradigms, and a longer familiarization period is necessary for long-term associative recognition memory than for non-associative memory. Public Library of Science 2021-07-30 /pmc/articles/PMC8323955/ /pubmed/34329332 http://dx.doi.org/10.1371/journal.pone.0254570 Text en © 2021 Shimoda et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Shimoda, Shota Ozawa, Takaaki Ichitani, Yukio Yamada, Kazuo Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test |
title | Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test |
title_full | Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test |
title_fullStr | Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test |
title_full_unstemmed | Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test |
title_short | Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test |
title_sort | long-term associative memory in rats: effects of familiarization period in object-place-context recognition test |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323955/ https://www.ncbi.nlm.nih.gov/pubmed/34329332 http://dx.doi.org/10.1371/journal.pone.0254570 |
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