The major mechanism of melanoma mutations is based on deamination of cytosine in pyrimidine dimers as determined by circle damage sequencing

Sunlight-associated melanomas carry a unique C-to-T mutation signature. UVB radiation induces cyclobutane pyrimidine dimers (CPDs) as the major form of DNA damage, but the mechanism of how CPDs cause mutations is unclear. To map CPDs at single-base resolution genome wide, we developed the circle dam...

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Detalles Bibliográficos
Autores principales: Jin, Seung-Gi, Pettinga, Dean, Johnson, Jennifer, Li, Peipei, Pfeifer, Gerd P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324051/
https://www.ncbi.nlm.nih.gov/pubmed/34330711
http://dx.doi.org/10.1126/sciadv.abi6508

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