FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats

FAN1, a DNA structure-specific nuclease, interacts with MLH1, but the repair pathways in which this complex acts are unknown. FAN1 processes DNA interstrand crosslinks (ICLs) and FAN1 variants are modifiers of the neurodegenerative Huntington’s disease (HD), presumably by regulating HD-causing CAG r...

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Detalles Bibliográficos
Autores principales: Porro, Antonio, Mohiuddin, Mohiuddin, Zurfluh, Christina, Spegg, Vincent, Dai, Jingqi, Iehl, Florence, Ropars, Virginie, Collotta, Giulio, Fishwick, Keri M., Mozaffari, Nour L., Guérois, Raphaël, Jiricny, Josef, Altmeyer, Matthias, Charbonnier, Jean-Baptiste, Pearson, Christopher E., Sartori, Alessandro A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324060/
https://www.ncbi.nlm.nih.gov/pubmed/34330701
http://dx.doi.org/10.1126/sciadv.abf7906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324060/
https://www.ncbi.nlm.nih.gov/pubmed/34330701
http://dx.doi.org/10.1126/sciadv.abf7906

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