Secondary Immune Thrombocytopenia (ITP) Associated with ChAdOx1 Covid-19 Vaccination – A Case Report

Novel mRNA and vector-based covid-19 vaccinations have shown high efficacy in preventing symptomatic COVID-19 infections. Compared with the number of performed vaccinations, rates of severe side effects seem low. Rare prothrombotic coagulation disorders with suspected association to ChAdOx1 nCoV-19...

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Autores principales: Koch, Martin, Fuld, Sybille, Middeke, Jan M., Fantana, Julia, von Bonin, Simone, Beyer-Westendorf, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324423/
https://www.ncbi.nlm.nih.gov/pubmed/34377889
http://dx.doi.org/10.1055/s-0041-1731774
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author Koch, Martin
Fuld, Sybille
Middeke, Jan M.
Fantana, Julia
von Bonin, Simone
Beyer-Westendorf, Jan
author_facet Koch, Martin
Fuld, Sybille
Middeke, Jan M.
Fantana, Julia
von Bonin, Simone
Beyer-Westendorf, Jan
author_sort Koch, Martin
collection PubMed
description Novel mRNA and vector-based covid-19 vaccinations have shown high efficacy in preventing symptomatic COVID-19 infections. Compared with the number of performed vaccinations, rates of severe side effects seem low. Rare prothrombotic coagulation disorders with suspected association to ChAdOx1 nCoV-19 (AstraZeneca) have been reported. These cases have gathered considerable media attention and caused a temporary pause of usage of the AstraZeneca vaccine in Europe and several other countries and are currently discussed as vaccine-induced immune thrombotic thrombocytopenia (VITT). However, hemorrhagic complications from ChAdOx1 nCoV-19 vaccination have also been reported but, so far, received less public attention despite considerable potential for life-threatening complications. Here we present a case of severe immune thrombocytopenia after ChAdOx1 covid-19 vaccination and its successful primary management.
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spelling pubmed-83244232021-08-09 Secondary Immune Thrombocytopenia (ITP) Associated with ChAdOx1 Covid-19 Vaccination – A Case Report Koch, Martin Fuld, Sybille Middeke, Jan M. Fantana, Julia von Bonin, Simone Beyer-Westendorf, Jan TH Open Novel mRNA and vector-based covid-19 vaccinations have shown high efficacy in preventing symptomatic COVID-19 infections. Compared with the number of performed vaccinations, rates of severe side effects seem low. Rare prothrombotic coagulation disorders with suspected association to ChAdOx1 nCoV-19 (AstraZeneca) have been reported. These cases have gathered considerable media attention and caused a temporary pause of usage of the AstraZeneca vaccine in Europe and several other countries and are currently discussed as vaccine-induced immune thrombotic thrombocytopenia (VITT). However, hemorrhagic complications from ChAdOx1 nCoV-19 vaccination have also been reported but, so far, received less public attention despite considerable potential for life-threatening complications. Here we present a case of severe immune thrombocytopenia after ChAdOx1 covid-19 vaccination and its successful primary management. Georg Thieme Verlag KG 2021-07-30 /pmc/articles/PMC8324423/ /pubmed/34377889 http://dx.doi.org/10.1055/s-0041-1731774 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Koch, Martin
Fuld, Sybille
Middeke, Jan M.
Fantana, Julia
von Bonin, Simone
Beyer-Westendorf, Jan
Secondary Immune Thrombocytopenia (ITP) Associated with ChAdOx1 Covid-19 Vaccination – A Case Report
title Secondary Immune Thrombocytopenia (ITP) Associated with ChAdOx1 Covid-19 Vaccination – A Case Report
title_full Secondary Immune Thrombocytopenia (ITP) Associated with ChAdOx1 Covid-19 Vaccination – A Case Report
title_fullStr Secondary Immune Thrombocytopenia (ITP) Associated with ChAdOx1 Covid-19 Vaccination – A Case Report
title_full_unstemmed Secondary Immune Thrombocytopenia (ITP) Associated with ChAdOx1 Covid-19 Vaccination – A Case Report
title_short Secondary Immune Thrombocytopenia (ITP) Associated with ChAdOx1 Covid-19 Vaccination – A Case Report
title_sort secondary immune thrombocytopenia (itp) associated with chadox1 covid-19 vaccination – a case report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324423/
https://www.ncbi.nlm.nih.gov/pubmed/34377889
http://dx.doi.org/10.1055/s-0041-1731774
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