Butyrate, a new microbiota-dependent player in CD8+ T cells immunity and cancer therapy?

The intestinal microbiota is a new promising avenue in cancer immunotherapy, but mechanisms remain elusive. He et al. demonstrate that butyrate, a bacterial metabolite, enhances the CD8+ T cell response and improve chemotherapy efficacy through ID2-dependent IL-12 signaling.

Detalles Bibliográficos
Autores principales: Danne, Camille, Sokol, Harry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Preview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324458/
https://www.ncbi.nlm.nih.gov/pubmed/34337557
http://dx.doi.org/10.1016/j.xcrm.2021.100328
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author Danne, Camille
Sokol, Harry
author_facet Danne, Camille
Sokol, Harry
author_sort Danne, Camille
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description The intestinal microbiota is a new promising avenue in cancer immunotherapy, but mechanisms remain elusive. He et al. demonstrate that butyrate, a bacterial metabolite, enhances the CD8+ T cell response and improve chemotherapy efficacy through ID2-dependent IL-12 signaling.
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spelling pubmed-83244582021-07-31 Butyrate, a new microbiota-dependent player in CD8+ T cells immunity and cancer therapy? Danne, Camille Sokol, Harry Cell Rep Med Preview The intestinal microbiota is a new promising avenue in cancer immunotherapy, but mechanisms remain elusive. He et al. demonstrate that butyrate, a bacterial metabolite, enhances the CD8+ T cell response and improve chemotherapy efficacy through ID2-dependent IL-12 signaling. Elsevier 2021-07-07 /pmc/articles/PMC8324458/ /pubmed/34337557 http://dx.doi.org/10.1016/j.xcrm.2021.100328 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preview
Danne, Camille
Sokol, Harry
Butyrate, a new microbiota-dependent player in CD8+ T cells immunity and cancer therapy?
title Butyrate, a new microbiota-dependent player in CD8+ T cells immunity and cancer therapy?
title_full Butyrate, a new microbiota-dependent player in CD8+ T cells immunity and cancer therapy?
title_fullStr Butyrate, a new microbiota-dependent player in CD8+ T cells immunity and cancer therapy?
title_full_unstemmed Butyrate, a new microbiota-dependent player in CD8+ T cells immunity and cancer therapy?
title_short Butyrate, a new microbiota-dependent player in CD8+ T cells immunity and cancer therapy?
title_sort butyrate, a new microbiota-dependent player in cd8+ t cells immunity and cancer therapy?
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324458/
https://www.ncbi.nlm.nih.gov/pubmed/34337557
http://dx.doi.org/10.1016/j.xcrm.2021.100328
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