EOMES and IL-10 regulate antitumor activity of T regulatory type 1 CD4(+) T cells in chronic lymphocytic leukemia

The transcription factor eomesodermin (EOMES) promotes interleukin (IL)-10 expression in CD4(+) T cells, which has been linked to immunosuppressive and cytotoxic activities. We detected cytotoxic, programmed cell death protein-1 (PD-1) and EOMES co-expressing CD4(+) T cells in lymph nodes (LNs) of p...

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Detalles Bibliográficos
Autores principales: Roessner, Philipp M., Llaó Cid, Laura, Lupar, Ekaterina, Roider, Tobias, Bordas, Marie, Schifflers, Christoph, Arseni, Lavinia, Gaupel, Ann-Christin, Kilpert, Fabian, Krötschel, Marit, Arnold, Sebastian J., Sellner, Leopold, Colomer, Dolors, Stilgenbauer, Stephan, Dietrich, Sascha, Lichter, Peter, Izcue, Ana, Seiffert, Martina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324479/
https://www.ncbi.nlm.nih.gov/pubmed/33526861
http://dx.doi.org/10.1038/s41375-021-01136-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324479/
https://www.ncbi.nlm.nih.gov/pubmed/33526861
http://dx.doi.org/10.1038/s41375-021-01136-1

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