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Uncoupling of gene expression from copy number presents therapeutic opportunities in aneuploid cancers

Uncoupling of mRNA expression from copy number (UECN) might be a strategy for cancer cells to a tolerate high degree of aneuploidy. To test the extent and role of UECN across cancers, we perform integrative multiomic analysis of The Cancer Genome Atlas (TCGA) dataset, encompassing ∼5,000 individual...

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Detalles Bibliográficos
Autores principales:	Mohanty, Vakul, Wang, Fang, Mills, Gordon B., Chen, Ken
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324495/ https://www.ncbi.nlm.nih.gov/pubmed/34337565 http://dx.doi.org/10.1016/j.xcrm.2021.100349

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