A Case of COVID-19-Associated Autoimmune Hemolytic Anemia With Hyperferritinemia in an Immunocompetent Host

We report an interesting case of a middle-aged gentleman who presented with diabetic ketoacidosis (DKA) and tested polymerase chain reaction (PCR) positive for COVID-19 infection. His hospital stay was complicated by acute kidney injury, hematuria, and normocytic anemia. Initial chest x-ray demonstr...

Descripción completa

Detalles Bibliográficos
Autores principales: Huda, Zoha, Jahangir, Abdullah, Sahra, Syeda, Rafay Khan Niazi, Muhammad, Anwar, Shamsuddin, Glaser, Allison, Jahangir, Ahmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324606/
https://www.ncbi.nlm.nih.gov/pubmed/34345558
http://dx.doi.org/10.7759/cureus.16078
_version_ 1783731416146640896
author Huda, Zoha
Jahangir, Abdullah
Sahra, Syeda
Rafay Khan Niazi, Muhammad
Anwar, Shamsuddin
Glaser, Allison
Jahangir, Ahmad
author_facet Huda, Zoha
Jahangir, Abdullah
Sahra, Syeda
Rafay Khan Niazi, Muhammad
Anwar, Shamsuddin
Glaser, Allison
Jahangir, Ahmad
author_sort Huda, Zoha
collection PubMed
description We report an interesting case of a middle-aged gentleman who presented with diabetic ketoacidosis (DKA) and tested polymerase chain reaction (PCR) positive for COVID-19 infection. His hospital stay was complicated by acute kidney injury, hematuria, and normocytic anemia. Initial chest x-ray demonstrated bibasilar opacities. D-dimer and C-reactive protein were elevated. During his hospital stay, his hemoglobin decreased from 13.4 g/dL to 9 g/dL, and further workup demonstrated ferritin of 49,081 ng/mL with lactate dehydrogenase of 1665 U/L. He was treated with prednisone and folic acid for autoimmune hemolytic anemia (AIHA). Ferritin was downtrended, and hemoglobin stabilized. As demonstrated by this case report and prior literature review, COVID-19 infection can be associated with AIHA.
format Online
Article
Text
id pubmed-8324606
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-83246062021-08-02 A Case of COVID-19-Associated Autoimmune Hemolytic Anemia With Hyperferritinemia in an Immunocompetent Host Huda, Zoha Jahangir, Abdullah Sahra, Syeda Rafay Khan Niazi, Muhammad Anwar, Shamsuddin Glaser, Allison Jahangir, Ahmad Cureus Infectious Disease We report an interesting case of a middle-aged gentleman who presented with diabetic ketoacidosis (DKA) and tested polymerase chain reaction (PCR) positive for COVID-19 infection. His hospital stay was complicated by acute kidney injury, hematuria, and normocytic anemia. Initial chest x-ray demonstrated bibasilar opacities. D-dimer and C-reactive protein were elevated. During his hospital stay, his hemoglobin decreased from 13.4 g/dL to 9 g/dL, and further workup demonstrated ferritin of 49,081 ng/mL with lactate dehydrogenase of 1665 U/L. He was treated with prednisone and folic acid for autoimmune hemolytic anemia (AIHA). Ferritin was downtrended, and hemoglobin stabilized. As demonstrated by this case report and prior literature review, COVID-19 infection can be associated with AIHA. Cureus 2021-06-30 /pmc/articles/PMC8324606/ /pubmed/34345558 http://dx.doi.org/10.7759/cureus.16078 Text en Copyright © 2021, Huda et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Infectious Disease
Huda, Zoha
Jahangir, Abdullah
Sahra, Syeda
Rafay Khan Niazi, Muhammad
Anwar, Shamsuddin
Glaser, Allison
Jahangir, Ahmad
A Case of COVID-19-Associated Autoimmune Hemolytic Anemia With Hyperferritinemia in an Immunocompetent Host
title A Case of COVID-19-Associated Autoimmune Hemolytic Anemia With Hyperferritinemia in an Immunocompetent Host
title_full A Case of COVID-19-Associated Autoimmune Hemolytic Anemia With Hyperferritinemia in an Immunocompetent Host
title_fullStr A Case of COVID-19-Associated Autoimmune Hemolytic Anemia With Hyperferritinemia in an Immunocompetent Host
title_full_unstemmed A Case of COVID-19-Associated Autoimmune Hemolytic Anemia With Hyperferritinemia in an Immunocompetent Host
title_short A Case of COVID-19-Associated Autoimmune Hemolytic Anemia With Hyperferritinemia in an Immunocompetent Host
title_sort case of covid-19-associated autoimmune hemolytic anemia with hyperferritinemia in an immunocompetent host
topic Infectious Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324606/
https://www.ncbi.nlm.nih.gov/pubmed/34345558
http://dx.doi.org/10.7759/cureus.16078
work_keys_str_mv AT hudazoha acaseofcovid19associatedautoimmunehemolyticanemiawithhyperferritinemiainanimmunocompetenthost
AT jahangirabdullah acaseofcovid19associatedautoimmunehemolyticanemiawithhyperferritinemiainanimmunocompetenthost
AT sahrasyeda acaseofcovid19associatedautoimmunehemolyticanemiawithhyperferritinemiainanimmunocompetenthost
AT rafaykhanniazimuhammad acaseofcovid19associatedautoimmunehemolyticanemiawithhyperferritinemiainanimmunocompetenthost
AT anwarshamsuddin acaseofcovid19associatedautoimmunehemolyticanemiawithhyperferritinemiainanimmunocompetenthost
AT glaserallison acaseofcovid19associatedautoimmunehemolyticanemiawithhyperferritinemiainanimmunocompetenthost
AT jahangirahmad acaseofcovid19associatedautoimmunehemolyticanemiawithhyperferritinemiainanimmunocompetenthost
AT hudazoha caseofcovid19associatedautoimmunehemolyticanemiawithhyperferritinemiainanimmunocompetenthost
AT jahangirabdullah caseofcovid19associatedautoimmunehemolyticanemiawithhyperferritinemiainanimmunocompetenthost
AT sahrasyeda caseofcovid19associatedautoimmunehemolyticanemiawithhyperferritinemiainanimmunocompetenthost
AT rafaykhanniazimuhammad caseofcovid19associatedautoimmunehemolyticanemiawithhyperferritinemiainanimmunocompetenthost
AT anwarshamsuddin caseofcovid19associatedautoimmunehemolyticanemiawithhyperferritinemiainanimmunocompetenthost
AT glaserallison caseofcovid19associatedautoimmunehemolyticanemiawithhyperferritinemiainanimmunocompetenthost
AT jahangirahmad caseofcovid19associatedautoimmunehemolyticanemiawithhyperferritinemiainanimmunocompetenthost

Ejemplares similares