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Evaluation of predictive scores for late and very late recurrence after cryoballoon-based ablation of atrial fibrillation
PURPOSE: Studies on predictive scores for very late recurrence (VLR) (recurrence later than 12 months) after second-generation cryoballoon-based pulmonary vein isolation (CB2-PVI) are sparse. We aimed to evaluate the frequency of late recurrence (LR) (later than 3 months) and VLR, and to validate pr...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324624/ https://www.ncbi.nlm.nih.gov/pubmed/32638187 http://dx.doi.org/10.1007/s10840-020-00778-y |
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author | Sano, Makoto Heeger, Christian-Hendrik Sciacca, Vanessa Große, Niels Keelani, Ahmad Fahimi, Behzad Hassan Hosseiny Phan, Huong Lan Reincke, Samuel Brüggemann, Ben Fink, Thomas Liosis, Spyridon Vogler, Julia Eitel, Charlotte Tilz, Roland Richard |
author_facet | Sano, Makoto Heeger, Christian-Hendrik Sciacca, Vanessa Große, Niels Keelani, Ahmad Fahimi, Behzad Hassan Hosseiny Phan, Huong Lan Reincke, Samuel Brüggemann, Ben Fink, Thomas Liosis, Spyridon Vogler, Julia Eitel, Charlotte Tilz, Roland Richard |
author_sort | Sano, Makoto |
collection | PubMed |
description | PURPOSE: Studies on predictive scores for very late recurrence (VLR) (recurrence later than 12 months) after second-generation cryoballoon-based pulmonary vein isolation (CB2-PVI) are sparse. We aimed to evaluate the frequency of late recurrence (LR) (later than 3 months) and VLR, and to validate predictive scores for LR and VLR after initial CB2-PVI. METHODS: A total of 288 patients undergoing initial CB2-PVI (66 ± 11 years, 46% paroxysmal) were retrospectively enrolled in the LR cohort. In the VLR cohort, 83 patients with recurrence within 3–12 months or with < 12-month follow-up were excluded. The predictive scores of arrhythmia recurrence were assessed, including the APPLE, DR-FLASH, PLAAF, BASE-AF(2), ATLAS, SCALE-CryoAF, and MB-LATER scores. RESULTS: During a mean follow-up of 15.3 ± 7.1 months, 188 of 288 (65.2%) patients remained in sinus rhythm without any recurrences. Thirty-two of 205 (15.6%) patients experienced VLR after a mean of 16.6 ± 5.6 months. Comparing the predictive values of these specific scores, the MB-LATER score showed a reliable trend toward greater risk of both LR and VLR (area under the curve in LR; 0.632, 0.637, 0.632, 0.637, 0.604, 0.725, and 0.691 (p = ns), VLR; 0.612, 0.636, 0.644, 0.586, 0.541, 0.633, and 0.680 (p = 0.038, vs. BASE-AF(2), respectively)). Kaplan-Meier analysis estimated patients with higher MB-LATER scores which had favorable outcomes (24-month freedom from LR; 26.0% vs. 56.7%, p < 0.0001, VLR; 53.4% vs. 82.1%, p = 0.013). CONCLUSION: The MB-LATER score provided more reliable predictive value for both LR and VLR. Patients with higher MB-LATER scores may benefit from more intensive long-term follow-up. |
format | Online Article Text |
id | pubmed-8324624 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-83246242021-08-02 Evaluation of predictive scores for late and very late recurrence after cryoballoon-based ablation of atrial fibrillation Sano, Makoto Heeger, Christian-Hendrik Sciacca, Vanessa Große, Niels Keelani, Ahmad Fahimi, Behzad Hassan Hosseiny Phan, Huong Lan Reincke, Samuel Brüggemann, Ben Fink, Thomas Liosis, Spyridon Vogler, Julia Eitel, Charlotte Tilz, Roland Richard J Interv Card Electrophysiol Article PURPOSE: Studies on predictive scores for very late recurrence (VLR) (recurrence later than 12 months) after second-generation cryoballoon-based pulmonary vein isolation (CB2-PVI) are sparse. We aimed to evaluate the frequency of late recurrence (LR) (later than 3 months) and VLR, and to validate predictive scores for LR and VLR after initial CB2-PVI. METHODS: A total of 288 patients undergoing initial CB2-PVI (66 ± 11 years, 46% paroxysmal) were retrospectively enrolled in the LR cohort. In the VLR cohort, 83 patients with recurrence within 3–12 months or with < 12-month follow-up were excluded. The predictive scores of arrhythmia recurrence were assessed, including the APPLE, DR-FLASH, PLAAF, BASE-AF(2), ATLAS, SCALE-CryoAF, and MB-LATER scores. RESULTS: During a mean follow-up of 15.3 ± 7.1 months, 188 of 288 (65.2%) patients remained in sinus rhythm without any recurrences. Thirty-two of 205 (15.6%) patients experienced VLR after a mean of 16.6 ± 5.6 months. Comparing the predictive values of these specific scores, the MB-LATER score showed a reliable trend toward greater risk of both LR and VLR (area under the curve in LR; 0.632, 0.637, 0.632, 0.637, 0.604, 0.725, and 0.691 (p = ns), VLR; 0.612, 0.636, 0.644, 0.586, 0.541, 0.633, and 0.680 (p = 0.038, vs. BASE-AF(2), respectively)). Kaplan-Meier analysis estimated patients with higher MB-LATER scores which had favorable outcomes (24-month freedom from LR; 26.0% vs. 56.7%, p < 0.0001, VLR; 53.4% vs. 82.1%, p = 0.013). CONCLUSION: The MB-LATER score provided more reliable predictive value for both LR and VLR. Patients with higher MB-LATER scores may benefit from more intensive long-term follow-up. Springer US 2020-07-07 2021 /pmc/articles/PMC8324624/ /pubmed/32638187 http://dx.doi.org/10.1007/s10840-020-00778-y Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Sano, Makoto Heeger, Christian-Hendrik Sciacca, Vanessa Große, Niels Keelani, Ahmad Fahimi, Behzad Hassan Hosseiny Phan, Huong Lan Reincke, Samuel Brüggemann, Ben Fink, Thomas Liosis, Spyridon Vogler, Julia Eitel, Charlotte Tilz, Roland Richard Evaluation of predictive scores for late and very late recurrence after cryoballoon-based ablation of atrial fibrillation |
title | Evaluation of predictive scores for late and very late recurrence after cryoballoon-based ablation of atrial fibrillation |
title_full | Evaluation of predictive scores for late and very late recurrence after cryoballoon-based ablation of atrial fibrillation |
title_fullStr | Evaluation of predictive scores for late and very late recurrence after cryoballoon-based ablation of atrial fibrillation |
title_full_unstemmed | Evaluation of predictive scores for late and very late recurrence after cryoballoon-based ablation of atrial fibrillation |
title_short | Evaluation of predictive scores for late and very late recurrence after cryoballoon-based ablation of atrial fibrillation |
title_sort | evaluation of predictive scores for late and very late recurrence after cryoballoon-based ablation of atrial fibrillation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324624/ https://www.ncbi.nlm.nih.gov/pubmed/32638187 http://dx.doi.org/10.1007/s10840-020-00778-y |
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