Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis

Visceral Leishmaniasis (VL), a potentially fatal disease is caused by Leishmania donovani parasites with no vaccine available. Here we produced a dermotropic live attenuated centrin gene deleted Leishmania major (LmCen(−/−)) vaccine under Good Laboratory Practices and demonstrated that a single intr...

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Detalles Bibliográficos
Autores principales: Karmakar, Subir, Ismail, Nevien, Oliveira, Fabiano, Oristian, James, Zhang, Wen Wei, Kaviraj, Swarnendu, Singh, Kamaleshwar P., Mondal, Abhishek, Das, Sushmita, Pandey, Krishna, Bhattacharya, Parna, Volpedo, Greta, Gannavaram, Sreenivas, Satoskar, Monika, Satoskar, Sanika, Sastry, Rajiv M., Oljuskin, Timur, Sepahpour, Telly, Meneses, Claudio, Hamano, Shinjiro, Das, Pradeep, Matlashewski, Greg, Singh, Sanjay, Kamhawi, Shaden, Dey, Ranadhir, Valenzuela, Jesus G., Satoskar, Abhay, Nakhasi, Hira L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324786/
https://www.ncbi.nlm.nih.gov/pubmed/34330999
http://dx.doi.org/10.1038/s42003-021-02446-x

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