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Association of SDF-1 Gene Polymorphism with Increased Risk of Acute Myeloid Leukemia Patients
BACKGROUND: Acute myeloid leukemia (AML) is a heterogenous group of disorders that emerge from the malignant transformation of hematopoietic stem cells. Chemokine stromal cell-derived factor 1(SDF-1) and its receptor CXC receptor 4 (CXCR4) has an essential role in dissemination of blast cells. Study...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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West Asia Organization for Cancer Prevention
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325146/ https://www.ncbi.nlm.nih.gov/pubmed/33906294 http://dx.doi.org/10.31557/APJCP.2021.22.4.1035 |
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author | Aladle, Doaa Abd Allah M Ghannam, Mayada A El-Ashwah, Shaimaa Ghobrial, F E I Mortada, Metwaly Ibrahim |
author_facet | Aladle, Doaa Abd Allah M Ghannam, Mayada A El-Ashwah, Shaimaa Ghobrial, F E I Mortada, Metwaly Ibrahim |
author_sort | Aladle, Doaa Abd Allah M |
collection | PubMed |
description | BACKGROUND: Acute myeloid leukemia (AML) is a heterogenous group of disorders that emerge from the malignant transformation of hematopoietic stem cells. Chemokine stromal cell-derived factor 1(SDF-1) and its receptor CXC receptor 4 (CXCR4) has an essential role in dissemination of blast cells. Study aimed to detect CXCR4 expression and the SDF-1 (rs1801157) gene polymorphisms and correlate them with prognosis and outcome in AML patients. SUBJECTS AND METHODS: The study was conducted on 60 de-novo AML patients, and 60 healthy controls. SDF-1 (rs1801157) gene polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and CXCR4 expression was done using flow cytometry analysis. RESULTS: SDF-1 dominant model (AG+AA) had higher risk AML (p 0.002). CXCR4 positive cases were associated significantly with toxic manifestations (p 0.019), lower CR rates (p 0.004), and unfavorable cytogenetics (p 0.027). Multivariate analysis showed that combined CXCR4positive with dominant SDF-1 considered as independent prognostic factor for shorter overall survival (OS) in AML patients (p 0.031). CONCLUSION: SDF-1 dominant model had a higher risk to develop AML, and CXCR4 positive expression predicts poor prognosis in AML patients and it could represent a targeted therapy in AML. In addition, CXCR4 could be easily integrated into the initial routine diagnostic work up of AML. |
format | Online Article Text |
id | pubmed-8325146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | West Asia Organization for Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-83251462021-08-06 Association of SDF-1 Gene Polymorphism with Increased Risk of Acute Myeloid Leukemia Patients Aladle, Doaa Abd Allah M Ghannam, Mayada A El-Ashwah, Shaimaa Ghobrial, F E I Mortada, Metwaly Ibrahim Asian Pac J Cancer Prev Research Article BACKGROUND: Acute myeloid leukemia (AML) is a heterogenous group of disorders that emerge from the malignant transformation of hematopoietic stem cells. Chemokine stromal cell-derived factor 1(SDF-1) and its receptor CXC receptor 4 (CXCR4) has an essential role in dissemination of blast cells. Study aimed to detect CXCR4 expression and the SDF-1 (rs1801157) gene polymorphisms and correlate them with prognosis and outcome in AML patients. SUBJECTS AND METHODS: The study was conducted on 60 de-novo AML patients, and 60 healthy controls. SDF-1 (rs1801157) gene polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and CXCR4 expression was done using flow cytometry analysis. RESULTS: SDF-1 dominant model (AG+AA) had higher risk AML (p 0.002). CXCR4 positive cases were associated significantly with toxic manifestations (p 0.019), lower CR rates (p 0.004), and unfavorable cytogenetics (p 0.027). Multivariate analysis showed that combined CXCR4positive with dominant SDF-1 considered as independent prognostic factor for shorter overall survival (OS) in AML patients (p 0.031). CONCLUSION: SDF-1 dominant model had a higher risk to develop AML, and CXCR4 positive expression predicts poor prognosis in AML patients and it could represent a targeted therapy in AML. In addition, CXCR4 could be easily integrated into the initial routine diagnostic work up of AML. West Asia Organization for Cancer Prevention 2021-04 /pmc/articles/PMC8325146/ /pubmed/33906294 http://dx.doi.org/10.31557/APJCP.2021.22.4.1035 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Aladle, Doaa Abd Allah M Ghannam, Mayada A El-Ashwah, Shaimaa Ghobrial, F E I Mortada, Metwaly Ibrahim Association of SDF-1 Gene Polymorphism with Increased Risk of Acute Myeloid Leukemia Patients |
title | Association of SDF-1 Gene Polymorphism with Increased Risk of Acute Myeloid Leukemia Patients |
title_full | Association of SDF-1 Gene Polymorphism with Increased Risk of Acute Myeloid Leukemia Patients |
title_fullStr | Association of SDF-1 Gene Polymorphism with Increased Risk of Acute Myeloid Leukemia Patients |
title_full_unstemmed | Association of SDF-1 Gene Polymorphism with Increased Risk of Acute Myeloid Leukemia Patients |
title_short | Association of SDF-1 Gene Polymorphism with Increased Risk of Acute Myeloid Leukemia Patients |
title_sort | association of sdf-1 gene polymorphism with increased risk of acute myeloid leukemia patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325146/ https://www.ncbi.nlm.nih.gov/pubmed/33906294 http://dx.doi.org/10.31557/APJCP.2021.22.4.1035 |
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