Cargando…

Prognostic significance of occult lymph node metastases in breast cancer: a meta-analysis

BACKGROUND: Occult metastases in axillary lymph nodes have been reported to be associated with poor prognosis in patients with breast cancer. However, studies on the prognostic value of occult metastases have shown controversial results. This meta-analysis aimed to evaluate the prognostic significan...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Guixin, Zhang, Shuhao, Wang, Meiling, Liu, Lin, Liu, Yaqian, Tang, Lianjun, Bai, He, Zhao, Haidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325175/
https://www.ncbi.nlm.nih.gov/pubmed/34330233
http://dx.doi.org/10.1186/s12885-021-08582-1
_version_ 1783731513144115200
author Wang, Guixin
Zhang, Shuhao
Wang, Meiling
Liu, Lin
Liu, Yaqian
Tang, Lianjun
Bai, He
Zhao, Haidong
author_facet Wang, Guixin
Zhang, Shuhao
Wang, Meiling
Liu, Lin
Liu, Yaqian
Tang, Lianjun
Bai, He
Zhao, Haidong
author_sort Wang, Guixin
collection PubMed
description BACKGROUND: Occult metastases in axillary lymph nodes have been reported to be associated with poor prognosis in patients with breast cancer. However, studies on the prognostic value of occult metastases have shown controversial results. This meta-analysis aimed to evaluate the prognostic significance of occult lymph node metastases in breast cancer. METHODS: Studies published until May, 2020, which retrospectively examined negative lymph nodes by stepsectioning and/or immunohistochemistry, were retrieved from MEDLINE, EMBASE, CNKI, and Cochrane Library databases. The pooled Relative Risk (RR) with 95% confidence interval (95% CI) for overall survival (OS) and disease-free survival (DFS) were calculated to examine the associations between occult metastases and prognosis. RESULTS: Patients with occult metastases in axillary lymph nodes had poorer five-year DFS (RR = 0.930; 95% CI = 0.907–0.954) and OS (RR = 0.972; 95% CI = 0.954–0.990). Furthermore, the DFS (RR = 0.887; 95% CI = 0.810–0.972) and OS (RR = 0.896; 95% CI = 0.856–0.939) of patients with occult metastases were significantly lower after a ten-year follow-up. CONCLUSIONS: Occult metastases in the axillary lymph nodes are associated with poorer DFS andOS of patients with breast cancer. Occult metastases might serve as a predictive factor of survival outcomes in patients with breast cancer.
format Online
Article
Text
id pubmed-8325175
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-83251752021-08-02 Prognostic significance of occult lymph node metastases in breast cancer: a meta-analysis Wang, Guixin Zhang, Shuhao Wang, Meiling Liu, Lin Liu, Yaqian Tang, Lianjun Bai, He Zhao, Haidong BMC Cancer Research BACKGROUND: Occult metastases in axillary lymph nodes have been reported to be associated with poor prognosis in patients with breast cancer. However, studies on the prognostic value of occult metastases have shown controversial results. This meta-analysis aimed to evaluate the prognostic significance of occult lymph node metastases in breast cancer. METHODS: Studies published until May, 2020, which retrospectively examined negative lymph nodes by stepsectioning and/or immunohistochemistry, were retrieved from MEDLINE, EMBASE, CNKI, and Cochrane Library databases. The pooled Relative Risk (RR) with 95% confidence interval (95% CI) for overall survival (OS) and disease-free survival (DFS) were calculated to examine the associations between occult metastases and prognosis. RESULTS: Patients with occult metastases in axillary lymph nodes had poorer five-year DFS (RR = 0.930; 95% CI = 0.907–0.954) and OS (RR = 0.972; 95% CI = 0.954–0.990). Furthermore, the DFS (RR = 0.887; 95% CI = 0.810–0.972) and OS (RR = 0.896; 95% CI = 0.856–0.939) of patients with occult metastases were significantly lower after a ten-year follow-up. CONCLUSIONS: Occult metastases in the axillary lymph nodes are associated with poorer DFS andOS of patients with breast cancer. Occult metastases might serve as a predictive factor of survival outcomes in patients with breast cancer. BioMed Central 2021-07-30 /pmc/articles/PMC8325175/ /pubmed/34330233 http://dx.doi.org/10.1186/s12885-021-08582-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wang, Guixin
Zhang, Shuhao
Wang, Meiling
Liu, Lin
Liu, Yaqian
Tang, Lianjun
Bai, He
Zhao, Haidong
Prognostic significance of occult lymph node metastases in breast cancer: a meta-analysis
title Prognostic significance of occult lymph node metastases in breast cancer: a meta-analysis
title_full Prognostic significance of occult lymph node metastases in breast cancer: a meta-analysis
title_fullStr Prognostic significance of occult lymph node metastases in breast cancer: a meta-analysis
title_full_unstemmed Prognostic significance of occult lymph node metastases in breast cancer: a meta-analysis
title_short Prognostic significance of occult lymph node metastases in breast cancer: a meta-analysis
title_sort prognostic significance of occult lymph node metastases in breast cancer: a meta-analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325175/
https://www.ncbi.nlm.nih.gov/pubmed/34330233
http://dx.doi.org/10.1186/s12885-021-08582-1
work_keys_str_mv AT wangguixin prognosticsignificanceofoccultlymphnodemetastasesinbreastcancerametaanalysis
AT zhangshuhao prognosticsignificanceofoccultlymphnodemetastasesinbreastcancerametaanalysis
AT wangmeiling prognosticsignificanceofoccultlymphnodemetastasesinbreastcancerametaanalysis
AT liulin prognosticsignificanceofoccultlymphnodemetastasesinbreastcancerametaanalysis
AT liuyaqian prognosticsignificanceofoccultlymphnodemetastasesinbreastcancerametaanalysis
AT tanglianjun prognosticsignificanceofoccultlymphnodemetastasesinbreastcancerametaanalysis
AT baihe prognosticsignificanceofoccultlymphnodemetastasesinbreastcancerametaanalysis
AT zhaohaidong prognosticsignificanceofoccultlymphnodemetastasesinbreastcancerametaanalysis