Cargando…

The Framingham risk score is associated with incident frailty, or is it?

BACKGROUNDS: Cardiovascular disease (CVD) risk factors are individually associated with frailty. This study examined whether Framingham CVD risk score (FRS) as an aggregate measure of CVD risk is associated with incident frailty among Chinese older adults. METHODS: This study used data from the Chin...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Hui, Ge, Mei-Ling, Dong, Birong, Xue, Qian-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325204/
https://www.ncbi.nlm.nih.gov/pubmed/34332530
http://dx.doi.org/10.1186/s12877-021-02387-4
_version_ 1783731519591809024
author Shi, Hui
Ge, Mei-Ling
Dong, Birong
Xue, Qian-Li
author_facet Shi, Hui
Ge, Mei-Ling
Dong, Birong
Xue, Qian-Li
author_sort Shi, Hui
collection PubMed
description BACKGROUNDS: Cardiovascular disease (CVD) risk factors are individually associated with frailty. This study examined whether Framingham CVD risk score (FRS) as an aggregate measure of CVD risk is associated with incident frailty among Chinese older adults. METHODS: This study used data from the China Health and Retirement Longitudinal Study. A sample of 3,618 participants aged 60 to 95 years and without CVD at baseline were followed for four years. FRS was calculated at baseline. Frailty status was defined as not-frail (0–2 criteria) or frail (3–5 criteria) based on the physical frailty phenotype consisting of five binary criteria (weakness, slowness, exhaustion, low activity level, and weight loss). After excluding subjects who were frail (n = 248) at baseline, discrete-time Cox regression was used to evaluate the relationship between FRS and incident frailty. RESULTS: During a median follow-up of 4.0 years, 323 (8 %) participants developed CVD and 318 (11 %) subjects had frailty onset. Higher FRS was associated with greater risk of incident frailty (HR: 1.03, 95 % CI: 1.00 to 1.06) after adjusting for education, marital status, obesity, comorbidity burden, and cognitive function. This association however was no longer significant (HR: 1.00, 95 % CI: 0.97 to 1.03) after additionally adjusting for age. These findings remained essentially unchanged after excluding subjects with depression (n = 590) at baseline or incident CVD (n = 323) during the 4-year follow-up. CONCLUSIONS: The FRS was not independently associated with incident frailty after adjusting for chronological age. More research is needed to assess the clinical utility of the FRS in predicting adverse health outcomes other than CVD in older adults. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-021-02387-4.
format Online
Article
Text
id pubmed-8325204
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-83252042021-08-02 The Framingham risk score is associated with incident frailty, or is it? Shi, Hui Ge, Mei-Ling Dong, Birong Xue, Qian-Li BMC Geriatr Research BACKGROUNDS: Cardiovascular disease (CVD) risk factors are individually associated with frailty. This study examined whether Framingham CVD risk score (FRS) as an aggregate measure of CVD risk is associated with incident frailty among Chinese older adults. METHODS: This study used data from the China Health and Retirement Longitudinal Study. A sample of 3,618 participants aged 60 to 95 years and without CVD at baseline were followed for four years. FRS was calculated at baseline. Frailty status was defined as not-frail (0–2 criteria) or frail (3–5 criteria) based on the physical frailty phenotype consisting of five binary criteria (weakness, slowness, exhaustion, low activity level, and weight loss). After excluding subjects who were frail (n = 248) at baseline, discrete-time Cox regression was used to evaluate the relationship between FRS and incident frailty. RESULTS: During a median follow-up of 4.0 years, 323 (8 %) participants developed CVD and 318 (11 %) subjects had frailty onset. Higher FRS was associated with greater risk of incident frailty (HR: 1.03, 95 % CI: 1.00 to 1.06) after adjusting for education, marital status, obesity, comorbidity burden, and cognitive function. This association however was no longer significant (HR: 1.00, 95 % CI: 0.97 to 1.03) after additionally adjusting for age. These findings remained essentially unchanged after excluding subjects with depression (n = 590) at baseline or incident CVD (n = 323) during the 4-year follow-up. CONCLUSIONS: The FRS was not independently associated with incident frailty after adjusting for chronological age. More research is needed to assess the clinical utility of the FRS in predicting adverse health outcomes other than CVD in older adults. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-021-02387-4. BioMed Central 2021-07-31 /pmc/articles/PMC8325204/ /pubmed/34332530 http://dx.doi.org/10.1186/s12877-021-02387-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Shi, Hui
Ge, Mei-Ling
Dong, Birong
Xue, Qian-Li
The Framingham risk score is associated with incident frailty, or is it?
title The Framingham risk score is associated with incident frailty, or is it?
title_full The Framingham risk score is associated with incident frailty, or is it?
title_fullStr The Framingham risk score is associated with incident frailty, or is it?
title_full_unstemmed The Framingham risk score is associated with incident frailty, or is it?
title_short The Framingham risk score is associated with incident frailty, or is it?
title_sort framingham risk score is associated with incident frailty, or is it?
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325204/
https://www.ncbi.nlm.nih.gov/pubmed/34332530
http://dx.doi.org/10.1186/s12877-021-02387-4
work_keys_str_mv AT shihui theframinghamriskscoreisassociatedwithincidentfrailtyorisit
AT gemeiling theframinghamriskscoreisassociatedwithincidentfrailtyorisit
AT dongbirong theframinghamriskscoreisassociatedwithincidentfrailtyorisit
AT xueqianli theframinghamriskscoreisassociatedwithincidentfrailtyorisit
AT shihui framinghamriskscoreisassociatedwithincidentfrailtyorisit
AT gemeiling framinghamriskscoreisassociatedwithincidentfrailtyorisit
AT dongbirong framinghamriskscoreisassociatedwithincidentfrailtyorisit
AT xueqianli framinghamriskscoreisassociatedwithincidentfrailtyorisit