Cargando…

Genetic alterations and functional networks of m6A RNA methylation regulators in pancreatic cancer based on data mining

BACKGROUND: Pancreatic cancer is a fatal malignancy of the digestive system and the 5-year survival rate remains low. Therefore, new molecular therapeutic targets are required to improve treatments, prognosis, and the survival of patients. N6-methyladenosine (m6A) is the most prevalent reversible me...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeng, Juan, Zhang, Heying, Tan, Yonggang, Wang, Zhe, Li, Yunwei, Yang, Xianghong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325265/ https://www.ncbi.nlm.nih.gov/pubmed/34330301 http://dx.doi.org/10.1186/s12967-021-03001-2

Ejemplares similares

m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling
por: Zeng, Juan, et al.
Publicado: (2021)

Retraction Notice to: m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling
por: Zeng, Juan, et al.
Publicado: (2022)

Subgroup analysis reveals molecular heterogeneity and provides potential precise treatment for pancreatic cancers
por: Zhang, Heying, et al.
Publicado: (2018)

ceRNA network analysis reveals prognostic markers for glioblastoma
por: Wang, Hao, et al.
Publicado: (2019)

MicroRNA-190b expression predicts a good prognosis and attenuates the malignant progression of pancreatic cancer by targeting MEF2C and TCF4
por: Li, Yunwei, et al.
Publicado: (2022)

Sp1-driven up-regulation of miR-19a decreases RHOB and promotes pancreatic cancer
por: Tan, Yonggang, et al.
Publicado: (2015)

Identification of m6A/m5C/m1A-associated LncRNAs for prognostic assessment and immunotherapy in pancreatic cancer
por: Huang, Yuquan, et al.
Publicado: (2023)

Glucose Regulates m(6)A Methylation of RNA in Pancreatic Islets
por: Bornaque, Florine, et al.
Publicado: (2022)

Identification of m6A-related genes and m6A RNA methylation regulators in pancreatic cancer and their association with survival
por: Geng, Yan, et al.
Publicado: (2020)

m6Acomet: large-scale functional prediction of individual m(6)A RNA methylation sites from an RNA co-methylation network
por: Wu, Xiangyu, et al.
Publicado: (2019)

Alteration of m6A RNA Methylation in Heart Failure With Preserved Ejection Fraction
por: Zhang, Beijian, et al.
Publicado: (2021)

Aggregation of lipid rafts activates c-met and c-Src in non-small cell lung cancer cells
por: Zeng, Juan, et al.
Publicado: (2018)

Construction and validation of m(6)A RNA methylation regulators associated prognostic model for gastrointestinal cancer
por: Miao, Yandong, et al.
Publicado: (2022)

Mining DNA methylation alterations towards a classification of placental pathologies
por: Wilson, Samantha L, et al.
Publicado: (2018)

Research on Embedded Multifunctional Data Mining Technology Based on Granular Computing
por: Li, Juan, et al.
Publicado: (2022)

m(6)A-Driver: Identifying Context-Specific mRNA m(6)A Methylation-Driven Gene Interaction Networks
por: Zhang, Song-Yao, et al.
Publicado: (2016)

Molecular mechanism analysis of m6A modification-related lncRNA-miRNA-mRNA network in regulating autophagy in acute pancreatitis
por: Li, Xiang, et al.
Publicado: (2022)

An experimental workflow for identifying RNA m(6)A alterations in cellular senescence by methylated RNA immunoprecipitation sequencing
por: Shi, Yue, et al.
Publicado: (2023)

Genetic alterations in pancreatic carcinoma
por: Schneider, Gunter, et al.
Publicado: (2003)

Altered m6A RNA methylation contributes to hippocampal memory deficits in Huntington’s disease mice
por: Pupak, Anika, et al.
Publicado: (2022)

Mining of RNA Methylation-Related Genes and Elucidation of Their Molecular Biology in Gallbladder Carcinoma
por: Yang, Changhong, et al.
Publicado: (2021)

Mining protein networks for synthetic genetic interactions
por: Paladugu, Sri R, et al.
Publicado: (2008)

RNA m(6)A methylation in cancer
por: Wang, Zhaotong, et al.
Publicado: (2022)

Transcription levels and prognostic significance of the NFI family members in human cancers
por: Li, Yuexian, et al.
Publicado: (2020)

Human pancreatic islet miRNA-mRNA networks of altered miRNAs due to glycemic status
por: Karagiannopoulos, Alexandros, et al.
Publicado: (2022)

Comprehensive Analysis of m6A RNA Methylation Regulators and the Immune Microenvironment to Aid Immunotherapy in Pancreatic Cancer
por: Guo, Yongdong, et al.
Publicado: (2021)

Methionine deficiency facilitates antitumour immunity by altering m(6)A methylation of immune checkpoint transcripts
por: Li, Ting, et al.
Publicado: (2023)

Mining Potential Drug Targets and Constructing Diagnostic Models for Heart Failure Based on miRNA-mRNA Networks
por: Fang, Xiangming, et al.
Publicado: (2022)

Alteration of N(6) -Methyladenosine mRNA Methylation in a Rat Model of Cerebral Ischemia–Reperfusion Injury
por: Yi, Dazhuang, et al.
Publicado: (2021)

Alterations of m6A RNA methylation regulators contribute to autophagy and immune infiltration in primary Sjögren’s syndrome
por: Cheng, Linlin, et al.
Publicado: (2022)

KIAA1429 mediates epithelial mesenchymal transition in sorafenib‐resistant hepatocellular carcinoma through m6A methylation modification
por: Kuang, Ye, et al.
Publicado: (2022)

Genetic Alterations and Transcriptional Expression of m(6)A RNA Methylation Regulators Drive a Malignant Phenotype and Have Clinical Prognostic Impact in Hepatocellular Carcinoma
por: Zhu, Gui-Qi, et al.
Publicado: (2020)

The role of mRNA m(6)A methylation in the nervous system
por: Li, Jiashuo, et al.
Publicado: (2019)

Joint Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer's Disease Cortex Reveals Altered miRNA Regulation
por: Nunez-Iglesias, Juan, et al.
Publicado: (2010)

IGF2BP2 promotes pancreatic carcinoma progression by enhancing the stability of B3GNT6 mRNA via m6A methylation
por: Cao, Pei, et al.
Publicado: (2022)

m(6)A Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Pancreatic Cancer
por: Sun, Mengyu, et al.
Publicado: (2021)

Genetic and Epigenetic Alterations in Pancreatic Carcinogenesis
por: Delpu, Yannick, et al.
Publicado: (2011)

Research progress of m(6)A methylation in prostate cancer
por: Zhang, Shou-Yi, et al.
Publicado: (2022)

Lipid metabolism and m(6)A RNA methylation are altered in lambs supplemented rumen-protected methionine and lysine in a low-protein diet
por: Gebeyew, Kefyalew, et al.
Publicado: (2022)

Integrating text mining, data mining, and network analysis for identifying genetic breast cancer trends
por: Jurca, Gabriela, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_6c3j4cu5um5inf5i7l9taisfo4