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TRIM28 inhibits alternative lengthening of telomere phenotypes by protecting SETDB1 from degradation
BACKGROUND: About 10–15% of tumor cells extend telomeres through the alternative lengthening of telomeres (ALT) mechanism, which is a recombination-dependent replication pathway. It is generally believed that ALT cells are related to the chromatin modification of telomeres. However, the mechanism of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325274/ https://www.ncbi.nlm.nih.gov/pubmed/34330324 http://dx.doi.org/10.1186/s13578-021-00660-y |