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TRIM28 inhibits alternative lengthening of telomere phenotypes by protecting SETDB1 from degradation

BACKGROUND: About 10–15% of tumor cells extend telomeres through the alternative lengthening of telomeres (ALT) mechanism, which is a recombination-dependent replication pathway. It is generally believed that ALT cells are related to the chromatin modification of telomeres. However, the mechanism of...

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Detalles Bibliográficos
Autores principales: Wang, Chuanle, Songyang, Zhou, Huang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325274/
https://www.ncbi.nlm.nih.gov/pubmed/34330324
http://dx.doi.org/10.1186/s13578-021-00660-y