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Expression of the human molecular chaperone domain Bri2 BRICHOS on a gram per liter scale with an E. coli fed-batch culture

BACKGROUND: The human Bri2 BRICHOS domain inhibits amyloid formation and toxicity and could be used as a therapeutic agent against amyloid diseases. For translation into clinical use, large quantities of correctly folded recombinant human (rh) Bri2 BRICHOS are required. To increase the expression an...

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Detalles Bibliográficos
Autores principales:	Schmuck, Benjamin, Chen, Gefei, Pelcman, Josef, Kronqvist, Nina, Rising, Anna, Johansson, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325310/ https://www.ncbi.nlm.nih.gov/pubmed/34330289 http://dx.doi.org/10.1186/s12934-021-01638-8

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