Cancer-associated fibroblast infiltration in gastric cancer: the discrepancy in subtypes pathways and immunosuppression

BACKGROUND: General role of cancer-associated fibroblast (CAF) and its infiltration characteristics in gastric cancer remains to be unknown. METHODS: We estimate CAF infiltration in bulk tumor tissue with RNA-seq data and analyzed its relationship with gastric cancer subtype, survival and immune mic...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Xu, Yao, Li, Qu, Jingkun, Liu, Lin, Lu, Ning, Wang, Jiansheng, Zhang, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325313/
https://www.ncbi.nlm.nih.gov/pubmed/34332586
http://dx.doi.org/10.1186/s12967-021-03012-z
_version_ 1783731540208910336
author Liu, Xu
Yao, Li
Qu, Jingkun
Liu, Lin
Lu, Ning
Wang, Jiansheng
Zhang, Jia
author_facet Liu, Xu
Yao, Li
Qu, Jingkun
Liu, Lin
Lu, Ning
Wang, Jiansheng
Zhang, Jia
author_sort Liu, Xu
collection PubMed
description BACKGROUND: General role of cancer-associated fibroblast (CAF) and its infiltration characteristics in gastric cancer remains to be unknown. METHODS: We estimate CAF infiltration in bulk tumor tissue with RNA-seq data and analyzed its relationship with gastric cancer subtype, survival and immune microenvironment. RESULTS: We revealed CAF intend to have higher infiltration in diffuse, genomically stable, and advanced gastric cancer. CAF is associated with immunosuppressive microenvironment. Wide transcriptomics alterations occur in high CAF infiltrated gastric cancer, PI3K/AKT, TGFB and Hedgehog pathway are remarkable in this procedure. We utilized receptor tyrosine kinases and TGFB pathway ligands to construct risk score system that can predict survival. CONCLUSION: Thus, CAF is associated with aggressive phenotype of gastric cancer and risk score based on RTK and TGFB pathway ligands expression is a promising tool for assessment of gastric cancer survival. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12967-021-03012-z.
format Online
Article
Text
id pubmed-8325313
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-83253132021-08-02 Cancer-associated fibroblast infiltration in gastric cancer: the discrepancy in subtypes pathways and immunosuppression Liu, Xu Yao, Li Qu, Jingkun Liu, Lin Lu, Ning Wang, Jiansheng Zhang, Jia J Transl Med Research BACKGROUND: General role of cancer-associated fibroblast (CAF) and its infiltration characteristics in gastric cancer remains to be unknown. METHODS: We estimate CAF infiltration in bulk tumor tissue with RNA-seq data and analyzed its relationship with gastric cancer subtype, survival and immune microenvironment. RESULTS: We revealed CAF intend to have higher infiltration in diffuse, genomically stable, and advanced gastric cancer. CAF is associated with immunosuppressive microenvironment. Wide transcriptomics alterations occur in high CAF infiltrated gastric cancer, PI3K/AKT, TGFB and Hedgehog pathway are remarkable in this procedure. We utilized receptor tyrosine kinases and TGFB pathway ligands to construct risk score system that can predict survival. CONCLUSION: Thus, CAF is associated with aggressive phenotype of gastric cancer and risk score based on RTK and TGFB pathway ligands expression is a promising tool for assessment of gastric cancer survival. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12967-021-03012-z. BioMed Central 2021-07-31 /pmc/articles/PMC8325313/ /pubmed/34332586 http://dx.doi.org/10.1186/s12967-021-03012-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Liu, Xu
Yao, Li
Qu, Jingkun
Liu, Lin
Lu, Ning
Wang, Jiansheng
Zhang, Jia
Cancer-associated fibroblast infiltration in gastric cancer: the discrepancy in subtypes pathways and immunosuppression
title Cancer-associated fibroblast infiltration in gastric cancer: the discrepancy in subtypes pathways and immunosuppression
title_full Cancer-associated fibroblast infiltration in gastric cancer: the discrepancy in subtypes pathways and immunosuppression
title_fullStr Cancer-associated fibroblast infiltration in gastric cancer: the discrepancy in subtypes pathways and immunosuppression
title_full_unstemmed Cancer-associated fibroblast infiltration in gastric cancer: the discrepancy in subtypes pathways and immunosuppression
title_short Cancer-associated fibroblast infiltration in gastric cancer: the discrepancy in subtypes pathways and immunosuppression
title_sort cancer-associated fibroblast infiltration in gastric cancer: the discrepancy in subtypes pathways and immunosuppression
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325313/
https://www.ncbi.nlm.nih.gov/pubmed/34332586
http://dx.doi.org/10.1186/s12967-021-03012-z
work_keys_str_mv AT liuxu cancerassociatedfibroblastinfiltrationingastriccancerthediscrepancyinsubtypespathwaysandimmunosuppression
AT yaoli cancerassociatedfibroblastinfiltrationingastriccancerthediscrepancyinsubtypespathwaysandimmunosuppression
AT qujingkun cancerassociatedfibroblastinfiltrationingastriccancerthediscrepancyinsubtypespathwaysandimmunosuppression
AT liulin cancerassociatedfibroblastinfiltrationingastriccancerthediscrepancyinsubtypespathwaysandimmunosuppression
AT luning cancerassociatedfibroblastinfiltrationingastriccancerthediscrepancyinsubtypespathwaysandimmunosuppression
AT wangjiansheng cancerassociatedfibroblastinfiltrationingastriccancerthediscrepancyinsubtypespathwaysandimmunosuppression
AT zhangjia cancerassociatedfibroblastinfiltrationingastriccancerthediscrepancyinsubtypespathwaysandimmunosuppression

Ejemplares similares