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Chromosome 10q26–driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium

Genome-wide association studies have identified the chromosome 10q26 (Chr10) locus, which contains the age-related maculopathy susceptibility 2 (ARMS2) and high temperature requirement A serine peptidase 1 (HTRA1) genes, as the strongest genetic risk factor for age-related macular degeneration (AMD)...

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Detalles Bibliográficos
Autores principales:	Williams, Brandi L., Seager, Nathan A., Gardiner, Jamie D., Pappas, Chris M., Cronin, Monica C., Amat di San Filippo, Cristina, Anstadt, Robert A., Liu, Jin, Toso, Marc A., Nichols, Lisa, Parnell, Timothy J., Eve, Jacqueline R., Bartel, Paul L., Zouache, Moussa A., Richards, Burt T., Hageman, Gregory S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325339/ https://www.ncbi.nlm.nih.gov/pubmed/34301870 http://dx.doi.org/10.1073/pnas.2103617118

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