Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility

Many bacteria harbor RNA-dependent nucleoside-triphosphatases of the DEAH/RHA family, whose molecular mechanisms and cellular functions are poorly understood. Here, we show that the Escherichia coli DEAH/RHA protein, HrpA, is an ATP-dependent 3 to 5′ RNA helicase and that the RNA helicase activity o...

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Detalles Bibliográficos
Autores principales: Grass, Lena M., Wollenhaupt, Jan, Barthel, Tatjana, Parfentev, Iwan, Urlaub, Henning, Loll, Bernhard, Klauck, Eberhard, Antelmann, Haike, Wahl, Markus C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325345/
https://www.ncbi.nlm.nih.gov/pubmed/34290142
http://dx.doi.org/10.1073/pnas.2100370118

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