miR-21a-5p Promotes Inflammation following Traumatic Spinal Cord Injury through Upregulation of Neurotoxic Reactive Astrocyte (A1) Polarization by Inhibiting the CNTF/STAT3/Nkrf Pathway

Reactive astrocytes are implicated in traumatic spinal cord injury (TSCI). Interestingly, naïve astrocytes can easily transform into neurotoxic reactive astrocytes (A1s) with inflammatory stimulation. Previous studies demonstrated that microRNA(miR)-21a-5p was up-regulated in spinal cord tissue afte...

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Detalles Bibliográficos
Autores principales: Zhang, Yining, Meng, Tingting, Chen, Jianan, Zhang, Ying, Kang, Jianning, Li, Xinyu, Yu, Guilian, Tian, Lige, Jin, Zhengxin, Dong, Hui, Zhang, Xiaodi, Ning, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326122/
https://www.ncbi.nlm.nih.gov/pubmed/34345208
http://dx.doi.org/10.7150/ijbs.60509

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