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Lipidomic and transcriptional analysis of the linoleoyl-omega-hydroxyceramide biosynthetic pathway in human psoriatic lesions

A complex assembly of lipids including fatty acids, cholesterol, and ceramides is vital to the integrity of the mammalian epidermal barrier. The formation of this barrier requires oxidation of the substrate fatty acid, linoleic acid (LA), which is initiated by the enzyme 12R-lipoxygenase (LOX). In t...

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Detalles Bibliográficos
Autores principales:	Tyrrell, Victoria J., Ali, Faraz, Boeglin, William E., Andrews, Robert, Burston, James, Birchall, James C., Ingram, John R., Murphy, Robert C., Piguet, Vincent, Brash, Alan R., O'Donnell, Valerie B., Thomas, Christopher P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326207/ https://www.ncbi.nlm.nih.gov/pubmed/34171322 http://dx.doi.org/10.1016/j.jlr.2021.100094

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