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Brucella cardiac implantable electronic device infection: A single-center case series
BACKGROUND: Cardiac implantable electronic devices (CIEDs), including implantable cardiac defibrillators, pacemakers, and cardiac resynchronization therapy devices, are lifesaving. However, device infections can lead to morbidity and mortality. The aim of this study was to describe the outcome of Br...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326340/ https://www.ncbi.nlm.nih.gov/pubmed/34367635 http://dx.doi.org/10.1016/j.amsu.2021.102568 |
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author | Elzein, Fatehi Alsufyani, Eid Al Hebaishi, Yahya Mosaad, Mohammed Alqurashi, Moayad Al Fagih, Ahmed |
author_facet | Elzein, Fatehi Alsufyani, Eid Al Hebaishi, Yahya Mosaad, Mohammed Alqurashi, Moayad Al Fagih, Ahmed |
author_sort | Elzein, Fatehi |
collection | PubMed |
description | BACKGROUND: Cardiac implantable electronic devices (CIEDs), including implantable cardiac defibrillators, pacemakers, and cardiac resynchronization therapy devices, are lifesaving. However, device infections can lead to morbidity and mortality. The aim of this study was to describe the outcome of Brucella CIED infections treated at our center, and to identify risk factors for Brucella infection in patients with CIEDs. Study Settings: Single-center study, Prince Sultan Military Medical City, Riyadh, KSA. METHODS: This case series included all Brucella-related CIED infections treated at a tertiary care center between 2009 and 2020. Data on patient demographics, clinical manifestations, predisposing factors, microbiology, treatment regimens, and outcomes were reviewed. RESULTS: Fifteen patients met the Brucella CIED infection criteria. The mean age was 62.2 years, and 80% were males. Common comorbidities included hypertension (73%), diabetes mellitus (67%), ischemic heart disease (47%), and chronic kidney disease (60%). The mean time to infection following the device implantation was 4.8 years (range: 5 months to 13 years). Fever was detected in 53% of patients, device site swelling in 47%, purulent discharge in 33%, and pain in 27%. The blood culture and serology results were positive in 73% and 80% of patients, respectively. All patients were treated with antibiotics, and the infected device was removed. Seven (46.6%) patients underwent reimplantation with a new device. One patient with dual Brucella and methicillin-sensitive Staphylococcus aureus infection died, and the other 14 patients recovered, with no recurrent infections reported to date. CONCLUSION: Brucella should be considered in CIED infections, particularly in endemic areas. Proper treatment and device removal are essential for good outcomes. |
format | Online Article Text |
id | pubmed-8326340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-83263402021-08-06 Brucella cardiac implantable electronic device infection: A single-center case series Elzein, Fatehi Alsufyani, Eid Al Hebaishi, Yahya Mosaad, Mohammed Alqurashi, Moayad Al Fagih, Ahmed Ann Med Surg (Lond) Cross-sectional Study BACKGROUND: Cardiac implantable electronic devices (CIEDs), including implantable cardiac defibrillators, pacemakers, and cardiac resynchronization therapy devices, are lifesaving. However, device infections can lead to morbidity and mortality. The aim of this study was to describe the outcome of Brucella CIED infections treated at our center, and to identify risk factors for Brucella infection in patients with CIEDs. Study Settings: Single-center study, Prince Sultan Military Medical City, Riyadh, KSA. METHODS: This case series included all Brucella-related CIED infections treated at a tertiary care center between 2009 and 2020. Data on patient demographics, clinical manifestations, predisposing factors, microbiology, treatment regimens, and outcomes were reviewed. RESULTS: Fifteen patients met the Brucella CIED infection criteria. The mean age was 62.2 years, and 80% were males. Common comorbidities included hypertension (73%), diabetes mellitus (67%), ischemic heart disease (47%), and chronic kidney disease (60%). The mean time to infection following the device implantation was 4.8 years (range: 5 months to 13 years). Fever was detected in 53% of patients, device site swelling in 47%, purulent discharge in 33%, and pain in 27%. The blood culture and serology results were positive in 73% and 80% of patients, respectively. All patients were treated with antibiotics, and the infected device was removed. Seven (46.6%) patients underwent reimplantation with a new device. One patient with dual Brucella and methicillin-sensitive Staphylococcus aureus infection died, and the other 14 patients recovered, with no recurrent infections reported to date. CONCLUSION: Brucella should be considered in CIED infections, particularly in endemic areas. Proper treatment and device removal are essential for good outcomes. Elsevier 2021-07-16 /pmc/articles/PMC8326340/ /pubmed/34367635 http://dx.doi.org/10.1016/j.amsu.2021.102568 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Cross-sectional Study Elzein, Fatehi Alsufyani, Eid Al Hebaishi, Yahya Mosaad, Mohammed Alqurashi, Moayad Al Fagih, Ahmed Brucella cardiac implantable electronic device infection: A single-center case series |
title | Brucella cardiac implantable electronic device infection: A single-center case series |
title_full | Brucella cardiac implantable electronic device infection: A single-center case series |
title_fullStr | Brucella cardiac implantable electronic device infection: A single-center case series |
title_full_unstemmed | Brucella cardiac implantable electronic device infection: A single-center case series |
title_short | Brucella cardiac implantable electronic device infection: A single-center case series |
title_sort | brucella cardiac implantable electronic device infection: a single-center case series |
topic | Cross-sectional Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326340/ https://www.ncbi.nlm.nih.gov/pubmed/34367635 http://dx.doi.org/10.1016/j.amsu.2021.102568 |
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