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Genetic Contribution of Synapse-Associated Protein 97 to Orbitofrontal–Striatal–Thalamic Circuitry Connectivity Changes in First-Episode Schizophrenia
Functional and structural disturbances in the orbitofrontal–striatal–thalamic circuitry are thought to be associated with mental symptoms and neurocognitive impairments in schizophrenia. This study tested whether synapse-associated protein 97 (SAP97), a reasonable candidate gene for schizophrenia, i...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326367/ https://www.ncbi.nlm.nih.gov/pubmed/34349683 http://dx.doi.org/10.3389/fpsyt.2021.691007 |
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author | Xu, Xusan Luo, Shucun Wen, Xia Wang, Xiaoxia Yin, Jingwen Luo, Xudong He, Bin Liang, Chunmei Xiong, Susu Zhu, Dongjian Fu, Jiawu Lv, Dong Dai, Zhun Lin, Juda Li, You Lin, Zhixiong Chen, Wubiao Luo, Zebin Wang, Yajun Ma, Guoda |
author_facet | Xu, Xusan Luo, Shucun Wen, Xia Wang, Xiaoxia Yin, Jingwen Luo, Xudong He, Bin Liang, Chunmei Xiong, Susu Zhu, Dongjian Fu, Jiawu Lv, Dong Dai, Zhun Lin, Juda Li, You Lin, Zhixiong Chen, Wubiao Luo, Zebin Wang, Yajun Ma, Guoda |
author_sort | Xu, Xusan |
collection | PubMed |
description | Functional and structural disturbances in the orbitofrontal–striatal–thalamic circuitry are thought to be associated with mental symptoms and neurocognitive impairments in schizophrenia. This study tested whether synapse-associated protein 97 (SAP97), a reasonable candidate gene for schizophrenia, is related to orbitofrontal–striatal–thalamic connection changes in first-episode schizophrenia (FES) patients and the clinical performance of schizophrenic patients by affecting this integrity. Fifty-two FES patients and 52 matched healthy controls were recruited. All subjects underwent genotyping via the improved multiplex ligation detection reaction technique and scanning with magnetic resonance imaging (MRI) to provide orbitofrontal–striatal–thalamic functional and structural imaging data. A two-way analysis of covariance model was employed to examine abnormal brain connectivities, and Spearman correlations were applied to estimate the relationships between brain connectivity and clinical manifestations. In the FES group, those with the SAP97 rs3915512 TT genotype showed lower structural and functional connectivity than A allele carriers between the orbitofrontal gyrus and striatum/thalamus. In the FES group, negative correlations were found between resting-state functional connectivity (RSFC) in the orbitofrontal gyrus and thalamus, and positive symptoms between structural connections in the orbitofrontal gyrus and striatum and cognitive functions, and positive correlations were suggested between RSFC in the orbitofrontal gyrus and thalamus and negative symptoms. Our findings suggested that the SAP97 rs3915512 polymorphism may be involved in mental symptoms and cognitive dysfunction in FES patients by influencing structural and functional connectivity of the orbitofrontal–striatal and orbitofrontal–thalamic regions. |
format | Online Article Text |
id | pubmed-8326367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83263672021-08-03 Genetic Contribution of Synapse-Associated Protein 97 to Orbitofrontal–Striatal–Thalamic Circuitry Connectivity Changes in First-Episode Schizophrenia Xu, Xusan Luo, Shucun Wen, Xia Wang, Xiaoxia Yin, Jingwen Luo, Xudong He, Bin Liang, Chunmei Xiong, Susu Zhu, Dongjian Fu, Jiawu Lv, Dong Dai, Zhun Lin, Juda Li, You Lin, Zhixiong Chen, Wubiao Luo, Zebin Wang, Yajun Ma, Guoda Front Psychiatry Psychiatry Functional and structural disturbances in the orbitofrontal–striatal–thalamic circuitry are thought to be associated with mental symptoms and neurocognitive impairments in schizophrenia. This study tested whether synapse-associated protein 97 (SAP97), a reasonable candidate gene for schizophrenia, is related to orbitofrontal–striatal–thalamic connection changes in first-episode schizophrenia (FES) patients and the clinical performance of schizophrenic patients by affecting this integrity. Fifty-two FES patients and 52 matched healthy controls were recruited. All subjects underwent genotyping via the improved multiplex ligation detection reaction technique and scanning with magnetic resonance imaging (MRI) to provide orbitofrontal–striatal–thalamic functional and structural imaging data. A two-way analysis of covariance model was employed to examine abnormal brain connectivities, and Spearman correlations were applied to estimate the relationships between brain connectivity and clinical manifestations. In the FES group, those with the SAP97 rs3915512 TT genotype showed lower structural and functional connectivity than A allele carriers between the orbitofrontal gyrus and striatum/thalamus. In the FES group, negative correlations were found between resting-state functional connectivity (RSFC) in the orbitofrontal gyrus and thalamus, and positive symptoms between structural connections in the orbitofrontal gyrus and striatum and cognitive functions, and positive correlations were suggested between RSFC in the orbitofrontal gyrus and thalamus and negative symptoms. Our findings suggested that the SAP97 rs3915512 polymorphism may be involved in mental symptoms and cognitive dysfunction in FES patients by influencing structural and functional connectivity of the orbitofrontal–striatal and orbitofrontal–thalamic regions. Frontiers Media S.A. 2021-07-19 /pmc/articles/PMC8326367/ /pubmed/34349683 http://dx.doi.org/10.3389/fpsyt.2021.691007 Text en Copyright © 2021 Xu, Luo, Wen, Wang, Yin, Luo, He, Liang, Xiong, Zhu, Fu, Lv, Dai, Lin, Li, Lin, Chen, Luo, Wang and Ma. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Xu, Xusan Luo, Shucun Wen, Xia Wang, Xiaoxia Yin, Jingwen Luo, Xudong He, Bin Liang, Chunmei Xiong, Susu Zhu, Dongjian Fu, Jiawu Lv, Dong Dai, Zhun Lin, Juda Li, You Lin, Zhixiong Chen, Wubiao Luo, Zebin Wang, Yajun Ma, Guoda Genetic Contribution of Synapse-Associated Protein 97 to Orbitofrontal–Striatal–Thalamic Circuitry Connectivity Changes in First-Episode Schizophrenia |
title | Genetic Contribution of Synapse-Associated Protein 97 to Orbitofrontal–Striatal–Thalamic Circuitry Connectivity Changes in First-Episode Schizophrenia |
title_full | Genetic Contribution of Synapse-Associated Protein 97 to Orbitofrontal–Striatal–Thalamic Circuitry Connectivity Changes in First-Episode Schizophrenia |
title_fullStr | Genetic Contribution of Synapse-Associated Protein 97 to Orbitofrontal–Striatal–Thalamic Circuitry Connectivity Changes in First-Episode Schizophrenia |
title_full_unstemmed | Genetic Contribution of Synapse-Associated Protein 97 to Orbitofrontal–Striatal–Thalamic Circuitry Connectivity Changes in First-Episode Schizophrenia |
title_short | Genetic Contribution of Synapse-Associated Protein 97 to Orbitofrontal–Striatal–Thalamic Circuitry Connectivity Changes in First-Episode Schizophrenia |
title_sort | genetic contribution of synapse-associated protein 97 to orbitofrontal–striatal–thalamic circuitry connectivity changes in first-episode schizophrenia |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326367/ https://www.ncbi.nlm.nih.gov/pubmed/34349683 http://dx.doi.org/10.3389/fpsyt.2021.691007 |
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