Cargando…

Genetic Contribution of Synapse-Associated Protein 97 to Orbitofrontal–Striatal–Thalamic Circuitry Connectivity Changes in First-Episode Schizophrenia

Functional and structural disturbances in the orbitofrontal–striatal–thalamic circuitry are thought to be associated with mental symptoms and neurocognitive impairments in schizophrenia. This study tested whether synapse-associated protein 97 (SAP97), a reasonable candidate gene for schizophrenia, i...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Xusan, Luo, Shucun, Wen, Xia, Wang, Xiaoxia, Yin, Jingwen, Luo, Xudong, He, Bin, Liang, Chunmei, Xiong, Susu, Zhu, Dongjian, Fu, Jiawu, Lv, Dong, Dai, Zhun, Lin, Juda, Li, You, Lin, Zhixiong, Chen, Wubiao, Luo, Zebin, Wang, Yajun, Ma, Guoda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326367/
https://www.ncbi.nlm.nih.gov/pubmed/34349683
http://dx.doi.org/10.3389/fpsyt.2021.691007
_version_ 1783731797882830848
author Xu, Xusan
Luo, Shucun
Wen, Xia
Wang, Xiaoxia
Yin, Jingwen
Luo, Xudong
He, Bin
Liang, Chunmei
Xiong, Susu
Zhu, Dongjian
Fu, Jiawu
Lv, Dong
Dai, Zhun
Lin, Juda
Li, You
Lin, Zhixiong
Chen, Wubiao
Luo, Zebin
Wang, Yajun
Ma, Guoda
author_facet Xu, Xusan
Luo, Shucun
Wen, Xia
Wang, Xiaoxia
Yin, Jingwen
Luo, Xudong
He, Bin
Liang, Chunmei
Xiong, Susu
Zhu, Dongjian
Fu, Jiawu
Lv, Dong
Dai, Zhun
Lin, Juda
Li, You
Lin, Zhixiong
Chen, Wubiao
Luo, Zebin
Wang, Yajun
Ma, Guoda
author_sort Xu, Xusan
collection PubMed
description Functional and structural disturbances in the orbitofrontal–striatal–thalamic circuitry are thought to be associated with mental symptoms and neurocognitive impairments in schizophrenia. This study tested whether synapse-associated protein 97 (SAP97), a reasonable candidate gene for schizophrenia, is related to orbitofrontal–striatal–thalamic connection changes in first-episode schizophrenia (FES) patients and the clinical performance of schizophrenic patients by affecting this integrity. Fifty-two FES patients and 52 matched healthy controls were recruited. All subjects underwent genotyping via the improved multiplex ligation detection reaction technique and scanning with magnetic resonance imaging (MRI) to provide orbitofrontal–striatal–thalamic functional and structural imaging data. A two-way analysis of covariance model was employed to examine abnormal brain connectivities, and Spearman correlations were applied to estimate the relationships between brain connectivity and clinical manifestations. In the FES group, those with the SAP97 rs3915512 TT genotype showed lower structural and functional connectivity than A allele carriers between the orbitofrontal gyrus and striatum/thalamus. In the FES group, negative correlations were found between resting-state functional connectivity (RSFC) in the orbitofrontal gyrus and thalamus, and positive symptoms between structural connections in the orbitofrontal gyrus and striatum and cognitive functions, and positive correlations were suggested between RSFC in the orbitofrontal gyrus and thalamus and negative symptoms. Our findings suggested that the SAP97 rs3915512 polymorphism may be involved in mental symptoms and cognitive dysfunction in FES patients by influencing structural and functional connectivity of the orbitofrontal–striatal and orbitofrontal–thalamic regions.
format Online
Article
Text
id pubmed-8326367
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-83263672021-08-03 Genetic Contribution of Synapse-Associated Protein 97 to Orbitofrontal–Striatal–Thalamic Circuitry Connectivity Changes in First-Episode Schizophrenia Xu, Xusan Luo, Shucun Wen, Xia Wang, Xiaoxia Yin, Jingwen Luo, Xudong He, Bin Liang, Chunmei Xiong, Susu Zhu, Dongjian Fu, Jiawu Lv, Dong Dai, Zhun Lin, Juda Li, You Lin, Zhixiong Chen, Wubiao Luo, Zebin Wang, Yajun Ma, Guoda Front Psychiatry Psychiatry Functional and structural disturbances in the orbitofrontal–striatal–thalamic circuitry are thought to be associated with mental symptoms and neurocognitive impairments in schizophrenia. This study tested whether synapse-associated protein 97 (SAP97), a reasonable candidate gene for schizophrenia, is related to orbitofrontal–striatal–thalamic connection changes in first-episode schizophrenia (FES) patients and the clinical performance of schizophrenic patients by affecting this integrity. Fifty-two FES patients and 52 matched healthy controls were recruited. All subjects underwent genotyping via the improved multiplex ligation detection reaction technique and scanning with magnetic resonance imaging (MRI) to provide orbitofrontal–striatal–thalamic functional and structural imaging data. A two-way analysis of covariance model was employed to examine abnormal brain connectivities, and Spearman correlations were applied to estimate the relationships between brain connectivity and clinical manifestations. In the FES group, those with the SAP97 rs3915512 TT genotype showed lower structural and functional connectivity than A allele carriers between the orbitofrontal gyrus and striatum/thalamus. In the FES group, negative correlations were found between resting-state functional connectivity (RSFC) in the orbitofrontal gyrus and thalamus, and positive symptoms between structural connections in the orbitofrontal gyrus and striatum and cognitive functions, and positive correlations were suggested between RSFC in the orbitofrontal gyrus and thalamus and negative symptoms. Our findings suggested that the SAP97 rs3915512 polymorphism may be involved in mental symptoms and cognitive dysfunction in FES patients by influencing structural and functional connectivity of the orbitofrontal–striatal and orbitofrontal–thalamic regions. Frontiers Media S.A. 2021-07-19 /pmc/articles/PMC8326367/ /pubmed/34349683 http://dx.doi.org/10.3389/fpsyt.2021.691007 Text en Copyright © 2021 Xu, Luo, Wen, Wang, Yin, Luo, He, Liang, Xiong, Zhu, Fu, Lv, Dai, Lin, Li, Lin, Chen, Luo, Wang and Ma. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Xu, Xusan
Luo, Shucun
Wen, Xia
Wang, Xiaoxia
Yin, Jingwen
Luo, Xudong
He, Bin
Liang, Chunmei
Xiong, Susu
Zhu, Dongjian
Fu, Jiawu
Lv, Dong
Dai, Zhun
Lin, Juda
Li, You
Lin, Zhixiong
Chen, Wubiao
Luo, Zebin
Wang, Yajun
Ma, Guoda
Genetic Contribution of Synapse-Associated Protein 97 to Orbitofrontal–Striatal–Thalamic Circuitry Connectivity Changes in First-Episode Schizophrenia
title Genetic Contribution of Synapse-Associated Protein 97 to Orbitofrontal–Striatal–Thalamic Circuitry Connectivity Changes in First-Episode Schizophrenia
title_full Genetic Contribution of Synapse-Associated Protein 97 to Orbitofrontal–Striatal–Thalamic Circuitry Connectivity Changes in First-Episode Schizophrenia
title_fullStr Genetic Contribution of Synapse-Associated Protein 97 to Orbitofrontal–Striatal–Thalamic Circuitry Connectivity Changes in First-Episode Schizophrenia
title_full_unstemmed Genetic Contribution of Synapse-Associated Protein 97 to Orbitofrontal–Striatal–Thalamic Circuitry Connectivity Changes in First-Episode Schizophrenia
title_short Genetic Contribution of Synapse-Associated Protein 97 to Orbitofrontal–Striatal–Thalamic Circuitry Connectivity Changes in First-Episode Schizophrenia
title_sort genetic contribution of synapse-associated protein 97 to orbitofrontal–striatal–thalamic circuitry connectivity changes in first-episode schizophrenia
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326367/
https://www.ncbi.nlm.nih.gov/pubmed/34349683
http://dx.doi.org/10.3389/fpsyt.2021.691007
work_keys_str_mv AT xuxusan geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia
AT luoshucun geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia
AT wenxia geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia
AT wangxiaoxia geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia
AT yinjingwen geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia
AT luoxudong geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia
AT hebin geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia
AT liangchunmei geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia
AT xiongsusu geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia
AT zhudongjian geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia
AT fujiawu geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia
AT lvdong geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia
AT daizhun geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia
AT linjuda geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia
AT liyou geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia
AT linzhixiong geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia
AT chenwubiao geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia
AT luozebin geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia
AT wangyajun geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia
AT maguoda geneticcontributionofsynapseassociatedprotein97toorbitofrontalstriatalthalamiccircuitryconnectivitychangesinfirstepisodeschizophrenia