Cargando…

Effects of Probiotics on Diarrhea and CD4 Cell Count in People Living With HIV: A Systematic Review and Meta-Analysis

Gastrointestinal probiotics play an important role in maintaining intestinal bacteria homeostasis. They might benefit people with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), which remains a global health challenge. However, there is a controversy regarding the efficac...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Xiao-Li, Chen, Ming-Hui, Geng, Shi-Tao, Yu, Juehua, Kuang, Yi-Qun, Luo, Hua-You, Wang, Kun-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326399/
https://www.ncbi.nlm.nih.gov/pubmed/34349637
http://dx.doi.org/10.3389/fphar.2021.570520
_version_ 1783731809536704512
author Zhang, Xiao-Li
Chen, Ming-Hui
Geng, Shi-Tao
Yu, Juehua
Kuang, Yi-Qun
Luo, Hua-You
Wang, Kun-Hua
author_facet Zhang, Xiao-Li
Chen, Ming-Hui
Geng, Shi-Tao
Yu, Juehua
Kuang, Yi-Qun
Luo, Hua-You
Wang, Kun-Hua
author_sort Zhang, Xiao-Li
collection PubMed
description Gastrointestinal probiotics play an important role in maintaining intestinal bacteria homeostasis. They might benefit people with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), which remains a global health challenge. However, there is a controversy regarding the efficacy of probiotics for the treatment of AIDS. This study systematically reviewed the evidence of the effects of existing probiotic interventions on AIDS and sought to provide information on the role of probiotics in the treatment of HIV/AIDS patients. A meta-analysis of studies identified by screening multiple databases was performed using a fixed-effects model in Review Manager 5.2 software. The meta-analysis showed that probiotics could reduce the incidence of AIDS-related diarrhea (RR = 0.60 (95% CI: 0.44–0.82), p = 0.001). The short-term use of probiotics (supplementation duration shorter than 30 days) did not reduce the incidence of diarrhea (RR = 0.76 (95% CI: 0.51–1.14), p = 0.19), while the long-term use of probiotics (supplementation duration longer than 30 days) reduced diarrhea (RR = 0.47 (95% CI: 0.29–0.76), p = 0.002). Probiotics had no effect on CD4 cell counts in HIV/AIDS patients (MD = 21.24 (95% CI: −12.95–55.39), p = 0.22). Our data support that probiotics were associated with an obvious reduction in AIDS-related diarrhea, which indicates the need for additional research on this potential preventive strategy for AIDS.
format Online
Article
Text
id pubmed-8326399
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-83263992021-08-03 Effects of Probiotics on Diarrhea and CD4 Cell Count in People Living With HIV: A Systematic Review and Meta-Analysis Zhang, Xiao-Li Chen, Ming-Hui Geng, Shi-Tao Yu, Juehua Kuang, Yi-Qun Luo, Hua-You Wang, Kun-Hua Front Pharmacol Pharmacology Gastrointestinal probiotics play an important role in maintaining intestinal bacteria homeostasis. They might benefit people with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), which remains a global health challenge. However, there is a controversy regarding the efficacy of probiotics for the treatment of AIDS. This study systematically reviewed the evidence of the effects of existing probiotic interventions on AIDS and sought to provide information on the role of probiotics in the treatment of HIV/AIDS patients. A meta-analysis of studies identified by screening multiple databases was performed using a fixed-effects model in Review Manager 5.2 software. The meta-analysis showed that probiotics could reduce the incidence of AIDS-related diarrhea (RR = 0.60 (95% CI: 0.44–0.82), p = 0.001). The short-term use of probiotics (supplementation duration shorter than 30 days) did not reduce the incidence of diarrhea (RR = 0.76 (95% CI: 0.51–1.14), p = 0.19), while the long-term use of probiotics (supplementation duration longer than 30 days) reduced diarrhea (RR = 0.47 (95% CI: 0.29–0.76), p = 0.002). Probiotics had no effect on CD4 cell counts in HIV/AIDS patients (MD = 21.24 (95% CI: −12.95–55.39), p = 0.22). Our data support that probiotics were associated with an obvious reduction in AIDS-related diarrhea, which indicates the need for additional research on this potential preventive strategy for AIDS. Frontiers Media S.A. 2021-07-19 /pmc/articles/PMC8326399/ /pubmed/34349637 http://dx.doi.org/10.3389/fphar.2021.570520 Text en Copyright © 2021 Zhang, Chen, Geng, Yu, Kuang, Luo and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhang, Xiao-Li
Chen, Ming-Hui
Geng, Shi-Tao
Yu, Juehua
Kuang, Yi-Qun
Luo, Hua-You
Wang, Kun-Hua
Effects of Probiotics on Diarrhea and CD4 Cell Count in People Living With HIV: A Systematic Review and Meta-Analysis
title Effects of Probiotics on Diarrhea and CD4 Cell Count in People Living With HIV: A Systematic Review and Meta-Analysis
title_full Effects of Probiotics on Diarrhea and CD4 Cell Count in People Living With HIV: A Systematic Review and Meta-Analysis
title_fullStr Effects of Probiotics on Diarrhea and CD4 Cell Count in People Living With HIV: A Systematic Review and Meta-Analysis
title_full_unstemmed Effects of Probiotics on Diarrhea and CD4 Cell Count in People Living With HIV: A Systematic Review and Meta-Analysis
title_short Effects of Probiotics on Diarrhea and CD4 Cell Count in People Living With HIV: A Systematic Review and Meta-Analysis
title_sort effects of probiotics on diarrhea and cd4 cell count in people living with hiv: a systematic review and meta-analysis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326399/
https://www.ncbi.nlm.nih.gov/pubmed/34349637
http://dx.doi.org/10.3389/fphar.2021.570520
work_keys_str_mv AT zhangxiaoli effectsofprobioticsondiarrheaandcd4cellcountinpeoplelivingwithhivasystematicreviewandmetaanalysis
AT chenminghui effectsofprobioticsondiarrheaandcd4cellcountinpeoplelivingwithhivasystematicreviewandmetaanalysis
AT gengshitao effectsofprobioticsondiarrheaandcd4cellcountinpeoplelivingwithhivasystematicreviewandmetaanalysis
AT yujuehua effectsofprobioticsondiarrheaandcd4cellcountinpeoplelivingwithhivasystematicreviewandmetaanalysis
AT kuangyiqun effectsofprobioticsondiarrheaandcd4cellcountinpeoplelivingwithhivasystematicreviewandmetaanalysis
AT luohuayou effectsofprobioticsondiarrheaandcd4cellcountinpeoplelivingwithhivasystematicreviewandmetaanalysis
AT wangkunhua effectsofprobioticsondiarrheaandcd4cellcountinpeoplelivingwithhivasystematicreviewandmetaanalysis