Cargando…

Electrochemical evaluation of the desloratadine at bismuth film electrode in the presence of cationic surfactant: Highly sensitive determination in pharmaceuticals and human urine by Linear sweep-cathodic stripping voltammetry

In this study, the electrochemical properties of desloratadine, which is in the second generation antihistamines group, were determined by bismuth film electrode (BiFE) in aqueous and aqueous/surfactant solutions. This compound gave an irreversible and diffusion-controlled reduction peak at about –1...

Descripción completa

Detalles Bibliográficos
Autores principales: ALTUNKAYNAK, Yalçın, ÖNAL, Günay, LEVENT, Abdulkadir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific and Technological Research Council of Turkey 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326470/
https://www.ncbi.nlm.nih.gov/pubmed/34385867
http://dx.doi.org/10.3906/kim-2101-42
_version_ 1783731829469085696
author ALTUNKAYNAK, Yalçın
ÖNAL, Günay
LEVENT, Abdulkadir
author_facet ALTUNKAYNAK, Yalçın
ÖNAL, Günay
LEVENT, Abdulkadir
author_sort ALTUNKAYNAK, Yalçın
collection PubMed
description In this study, the electrochemical properties of desloratadine, which is in the second generation antihistamines group, were determined by bismuth film electrode (BiFE) in aqueous and aqueous/surfactant solutions. This compound gave an irreversible and diffusion-controlled reduction peak at about –1.65 V by cyclic voltammetry. It was found that the addition of cationic surfactants (cetyltrimethylammonium bromide (CTAB) increased the reduction current signal of desloratadine, while anionic (sodium dodecylsulfate (SDS) and nonionic (Tween 80) surfactants were found to have an adverse effect. Using linear sweep-cathodic stripping voltammetry, the analytical signal showed a linear correlation with a concentration of 0.1 to 4 µM in 0.04 M Britton–Robinson solution (pH = 8.0) in the presence of 5 mM CTAB, while the detection limit was calculated to be 11.70 nM (3.64 μgL(–1)). This method has been successfully applied for the quantitation of desloratadine in pharmaceutical and urine samples without the need for any separation.
format Online
Article
Text
id pubmed-8326470
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Scientific and Technological Research Council of Turkey
record_format MEDLINE/PubMed
spelling pubmed-83264702021-08-11 Electrochemical evaluation of the desloratadine at bismuth film electrode in the presence of cationic surfactant: Highly sensitive determination in pharmaceuticals and human urine by Linear sweep-cathodic stripping voltammetry ALTUNKAYNAK, Yalçın ÖNAL, Günay LEVENT, Abdulkadir Turk J Chem Article In this study, the electrochemical properties of desloratadine, which is in the second generation antihistamines group, were determined by bismuth film electrode (BiFE) in aqueous and aqueous/surfactant solutions. This compound gave an irreversible and diffusion-controlled reduction peak at about –1.65 V by cyclic voltammetry. It was found that the addition of cationic surfactants (cetyltrimethylammonium bromide (CTAB) increased the reduction current signal of desloratadine, while anionic (sodium dodecylsulfate (SDS) and nonionic (Tween 80) surfactants were found to have an adverse effect. Using linear sweep-cathodic stripping voltammetry, the analytical signal showed a linear correlation with a concentration of 0.1 to 4 µM in 0.04 M Britton–Robinson solution (pH = 8.0) in the presence of 5 mM CTAB, while the detection limit was calculated to be 11.70 nM (3.64 μgL(–1)). This method has been successfully applied for the quantitation of desloratadine in pharmaceutical and urine samples without the need for any separation. The Scientific and Technological Research Council of Turkey 2021-06-30 /pmc/articles/PMC8326470/ /pubmed/34385867 http://dx.doi.org/10.3906/kim-2101-42 Text en Copyright © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Article
ALTUNKAYNAK, Yalçın
ÖNAL, Günay
LEVENT, Abdulkadir
Electrochemical evaluation of the desloratadine at bismuth film electrode in the presence of cationic surfactant: Highly sensitive determination in pharmaceuticals and human urine by Linear sweep-cathodic stripping voltammetry
title Electrochemical evaluation of the desloratadine at bismuth film electrode in the presence of cationic surfactant: Highly sensitive determination in pharmaceuticals and human urine by Linear sweep-cathodic stripping voltammetry
title_full Electrochemical evaluation of the desloratadine at bismuth film electrode in the presence of cationic surfactant: Highly sensitive determination in pharmaceuticals and human urine by Linear sweep-cathodic stripping voltammetry
title_fullStr Electrochemical evaluation of the desloratadine at bismuth film electrode in the presence of cationic surfactant: Highly sensitive determination in pharmaceuticals and human urine by Linear sweep-cathodic stripping voltammetry
title_full_unstemmed Electrochemical evaluation of the desloratadine at bismuth film electrode in the presence of cationic surfactant: Highly sensitive determination in pharmaceuticals and human urine by Linear sweep-cathodic stripping voltammetry
title_short Electrochemical evaluation of the desloratadine at bismuth film electrode in the presence of cationic surfactant: Highly sensitive determination in pharmaceuticals and human urine by Linear sweep-cathodic stripping voltammetry
title_sort electrochemical evaluation of the desloratadine at bismuth film electrode in the presence of cationic surfactant: highly sensitive determination in pharmaceuticals and human urine by linear sweep-cathodic stripping voltammetry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326470/
https://www.ncbi.nlm.nih.gov/pubmed/34385867
http://dx.doi.org/10.3906/kim-2101-42
work_keys_str_mv AT altunkaynakyalcın electrochemicalevaluationofthedesloratadineatbismuthfilmelectrodeinthepresenceofcationicsurfactanthighlysensitivedeterminationinpharmaceuticalsandhumanurinebylinearsweepcathodicstrippingvoltammetry
AT onalgunay electrochemicalevaluationofthedesloratadineatbismuthfilmelectrodeinthepresenceofcationicsurfactanthighlysensitivedeterminationinpharmaceuticalsandhumanurinebylinearsweepcathodicstrippingvoltammetry
AT leventabdulkadir electrochemicalevaluationofthedesloratadineatbismuthfilmelectrodeinthepresenceofcationicsurfactanthighlysensitivedeterminationinpharmaceuticalsandhumanurinebylinearsweepcathodicstrippingvoltammetry